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Random mutagenesis of the mouse genome: A strategy for discovering gene function and the molecular basis of disease

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dc.contributor.authorNguyen, Nhung
dc.contributor.authorJudd, Louise
dc.contributor.authorKalantzis, Anastasia
dc.contributor.authorWhittle, Belinda
dc.contributor.authorGiraud, Andy
dc.contributor.authorvan Driel, Ian
dc.date.accessioned2015-12-10T23:18:09Z
dc.date.issued2011
dc.date.updated2016-02-24T08:09:12Z
dc.description.abstractMutagenesis of mice with N-ethyl-N-nitrosourea (ENU) is a phenotype-driven approach to unravel gene function and discover new biological pathways. Phenotype-driven approaches have the advantage of making no assumptions about the function of genes and their products and have been successfully applied to the discovery of novel gene-phenotype relationships in many physiological systems. ENU mutagenesis of mice is used in many large-scale and more focused projects to generate and identify novel mouse models for the study of gene functions and human disease. This review examines the strategies and tools used in ENU mutagenesis screens to efficiently generate and identify functional mutations.
dc.identifier.issn0193-1857
dc.identifier.urihttp://hdl.handle.net/1885/65493
dc.publisherAmerican Physiological Society
dc.sourceAmerican Journal of Physiology: Gastrointestinal and Liver Physiology
dc.subjectKeywords: ankyrin; ethylnitrosourea; gene product; mutagenic agent; nucleic acid; thrombopoietin; thrombopoietin receptor; amino acid substitution; cancer research; carcinogenesis; chronic inflammation; DNA adduct; DNA polymorphism; enteritis; familial adenomatous Inflammatory bowel disease; Mouse models; N-ethyl-N-nitrosourea; Phenotype-driven
dc.titleRandom mutagenesis of the mouse genome: A strategy for discovering gene function and the molecular basis of disease
dc.typeJournal article
local.bibliographicCitation.issue1
local.bibliographicCitation.lastpageG11
local.bibliographicCitation.startpageG1
local.contributor.affiliationNguyen, Nhung, University of Melbourne
local.contributor.affiliationJudd, Louise, Murdoch Children's Research Institute
local.contributor.affiliationKalantzis, Anastasia, Murdoch Children's Research Institute
local.contributor.affiliationWhittle, Belinda, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationGiraud, Andy, University of Melbourne
local.contributor.affiliationvan Driel, Ian, University of Melbourne
local.contributor.authoruidWhittle, Belinda, u9503602
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor100109 - Transgenesis
local.identifier.ariespublicationf2965xPUB1114
local.identifier.citationvolume300
local.identifier.doi10.1152/ajpgi.00343.2010
local.identifier.scopusID2-s2.0-78650772777
local.identifier.thomsonID000285744300001
local.type.statusPublished Version

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