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Obeticholic Acid Ameliorates Non-Alcoholic Fatty Liver Disease By Improving Metabolic Profile In Dietary Obesity, But Not In Obese, Diabetic Foz/Foz Mice

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dc.contributor.authorHaczeyni, Fahrettin
dc.contributor.authorPoekes, Laurence
dc.contributor.authorBarn, Vanessa
dc.contributor.authorMridha, Auvro
dc.contributor.authorHaigh, W Geoffrey
dc.contributor.authorIoannou, George
dc.contributor.authorYeh, Matthew
dc.contributor.authorLeclercq, Isabelle
dc.contributor.authorTeoh, Narcissus
dc.contributor.authorFarrell, Geoffrey
dc.coverage.spatialBarcelona, Spain
dc.date.accessioned2022-06-08T05:48:30Z
dc.date.created13-17 April
dc.date.issued2016
dc.date.updated2021-01-17T07:19:38Z
dc.description.abstractBackground and Aims: The semi-synthetic farnesoid X receptor (FXR) agonist obeticholic acid (OCA) improves steatosis in patients with non-alcoholic steatohepatitis (NASH), but protective mechanisms remain unresolved. NASH is the outcome of complex interactions between nutrient supply, blood glucose, and adipose lipid storage capacity reflected by adipose morphology and inflammation. We therefore investigated the effects of OCA on glucose metabolism, adipose depots and liver in atherogenic dietfed wildtype (Wt) mice which develop dietary obesity, and Alms1 mutant (foz/foz) hyperphagic mice which develop metabolic obesity with diabetes.en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn0168-8278en_AU
dc.identifier.urihttp://hdl.handle.net/1885/267226
dc.language.isoen_AUen_AU
dc.publisherElsevier B.Ven_AU
dc.relation.ispartofseriesEASL, The International Liver Congress™ 2016en_AU
dc.rights© 2016 Elsevier B.Ven_AU
dc.sourceJournal of Hepatologyen_AU
dc.titleObeticholic Acid Ameliorates Non-Alcoholic Fatty Liver Disease By Improving Metabolic Profile In Dietary Obesity, But Not In Obese, Diabetic Foz/Foz Miceen_AU
dc.typeConference posteren_AU
local.bibliographicCitation.lastpageS678en_AU
local.bibliographicCitation.startpageS678en_AU
local.contributor.affiliationHaczeyni, Fahrettin, College of Health and Medicine, ANUen_AU
local.contributor.affiliationPoekes, Laurence, Universite Catholique de Louvainen_AU
local.contributor.affiliationBarn, Vanessa, College of Health and Medicine, ANUen_AU
local.contributor.affiliationMridha, Auvro, College of Health and Medicine, ANUen_AU
local.contributor.affiliationHaigh, W Geoffrey, University of Washingtonen_AU
local.contributor.affiliationIoannou, George, University of Washingtonen_AU
local.contributor.affiliationYeh, Matthew, University of Washingtonen_AU
local.contributor.affiliationLeclercq, Isabelle, Catholic University of Leuvenen_AU
local.contributor.affiliationTeoh, Narcissus, College of Health and Medicine, ANUen_AU
local.contributor.affiliationFarrell, Geoffrey, College of Health and Medicine, ANUen_AU
local.contributor.authoremailu4028700@anu.edu.auen_AU
local.contributor.authoruidHaczeyni, Fahrettin, u5076272en_AU
local.contributor.authoruidBarn, Vanessa, u4556662en_AU
local.contributor.authoruidMridha, Auvro, u5219668en_AU
local.contributor.authoruidTeoh, Narcissus, u4325419en_AU
local.contributor.authoruidFarrell, Geoffrey, u4028700en_AU
local.description.embargo2099-12-31
local.description.notesImported from ARIESen_AU
local.description.refereedYes
local.identifier.absfor110307 - Gastroenterology and Hepatologyen_AU
local.identifier.absseo920199 - Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classifieden_AU
local.identifier.ariespublicationu5369653xPUB219en_AU
local.identifier.doi10.1016/S0168-8278(16)01283-6en_AU
local.identifier.uidSubmittedByu5369653en_AU
local.publisher.urlhttp://www.journals.elsevier.com/journal-of-hepatology/en_AU
local.type.statusPublished Versionen_AU

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