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Genes, pathways and checkpoints in lymphocyte development and homeostasis

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dc.contributor.authorMiosge, Lisa
dc.contributor.authorGoodnow, Christopher
dc.date.accessioned2015-12-13T22:55:48Z
dc.date.issued2005
dc.date.updated2015-12-11T11:12:15Z
dc.description.abstractA plethora of genes involved in murine B and T cell development have been identified, and developmental pathways within the primary lymphoid tissues have been well delineated. The generation of a functional, but non-self reacting lymphocyte repertoire results from the completion of several checkpoints during lymphocyte development and competition for survival factors in the periphery. Improved knowledge of these developmental checkpoints and homeostatic mechanisms is critical for understanding human immunodeficiency, leukaemia/lymphoma and autoimmunity, which are conditions where checkpoints and homeostasis are likely to be deregulated.
dc.identifier.issn0818-9641
dc.identifier.urihttp://hdl.handle.net/1885/82671
dc.publisherBlackwell Publishing Ltd
dc.sourceImmunology and Cell Biology
dc.subjectKeywords: B lymphocyte receptor; CD23 antigen; CD79a antigen; CD79b antigen; cell surface marker; diacylglycerol; immunoglobulin D; interleukin 7; interleukin 7 receptor; L selectin; phosphoprotein; protein BLNK; protein kinase C; protein kinase Syk; T lymphocyte r B cell; Homeostasis; Lymphocyte development; Survival; T cell
dc.titleGenes, pathways and checkpoints in lymphocyte development and homeostasis
dc.typeJournal article
local.bibliographicCitation.lastpage335
local.bibliographicCitation.startpage318
local.contributor.affiliationMiosge, Lisa, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationGoodnow, Christopher, College of Medicine, Biology and Environment, ANU
local.contributor.authoruidMiosge, Lisa, u9817053
local.contributor.authoruidGoodnow, Christopher, u9710462
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor110706 - Immunogenetics (incl. Genetic Immunology)
local.identifier.ariespublicationMigratedxPub10896
local.identifier.citationvolume83
local.identifier.doi10.1111/j.1440-1711.2005.01353.x
local.identifier.scopusID2-s2.0-22944441630
local.type.statusPublished Version

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