De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kB signalling
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Authors
Wen, S
O'Rourke, Karen
Zhou, Honglin
Eby, Michael
Aravind, L
Seshagiri, Somasekar
Wu, Ping-Shi
Wiesmann, Christian
Baker, Rohan
Boone, David
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Macmillan Publishers Ltd
Abstract
NF-κB transcription factors mediate the effects of pro-inflammatory cytokines such as tumour necrosis factor-α and interleukin-1β. Failure to downregulate NF-κB transcriptional activity results in chronic inflammation and cell death, as observed in A2
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Nature
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2037-12-31
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