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IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative Diseases

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dc.contributor.authorwooff, yvette
dc.contributor.authorMan, Si Ming
dc.contributor.authorAggio-Bruce, Riemke
dc.contributor.authorNatoli, Riccardo
dc.contributor.authorFernando, Nilisha
dc.date.accessioned2022-11-30T04:53:53Z
dc.date.available2022-11-30T04:53:53Z
dc.date.issued2019
dc.date.updated2021-11-28T07:30:05Z
dc.description.abstractInflammation underpins and contributes to the pathogenesis of many retinal degenerative diseases. The recruitment and activation of both resident microglia and recruited macrophages, as well as the production of cytokines, are key contributing factors for progressive cell death in these diseases. In particular, the interleukin 1 (IL-1) family consisting of both pro- and anti-inflammatory cytokines has been shown to be pivotal in the mediation of innate immunity and contribute directly to a number of retinal degenerations, including Age-Related Macular Degeneration (AMD), diabetic retinopathy, retinitis pigmentosa, glaucoma, and retinopathy of prematurity (ROP). In this review, we will discuss the role of IL-1 family members and inflammasome signaling in retinal degenerative diseases, piecing together their contribution to retinal disease pathology, and identifying areas of research expansion required to further elucidate their function in the retina.en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn1664-3224en_AU
dc.identifier.urihttp://hdl.handle.net/1885/281415
dc.language.isoen_AUen_AU
dc.provenanceThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_AU
dc.publisherFrontiers Research Foundationen_AU
dc.rights© 2019 The authorsen_AU
dc.sourceFrontiers in Immunologyen_AU
dc.subjectretinal degenerationen_AU
dc.subjectIL-1 (interleukin-1)en_AU
dc.subjectage-related macular degeneration (AMD)en_AU
dc.subjectinflammationen_AU
dc.subjectcytokineen_AU
dc.subjectinflammasomeen_AU
dc.subjectIL-1ben_AU
dc.subjectphotoreceptor cell deathen_AU
dc.titleIL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative Diseasesen_AU
dc.typeJournal articleen_AU
local.contributor.affiliationWooff, Yvette, College of Health and Medicine, ANUen_AU
local.contributor.affiliationMan, Si Ming, College of Health and Medicine, ANUen_AU
local.contributor.affiliationAggio-Bruce, Riemke, College of Health and Medicine, ANUen_AU
local.contributor.affiliationNatoli, Riccardo, College of Health and Medicine, ANUen_AU
local.contributor.affiliationFernando, Nilisha, College of Health and Medicine, ANUen_AU
local.contributor.authoruidWooff, Yvette, u5978390en_AU
local.contributor.authoruidMan, Si Ming, u1036742en_AU
local.contributor.authoruidAggio-Bruce, Riemke, u5333366en_AU
local.contributor.authoruidNatoli, Riccardo, u4100537en_AU
local.contributor.authoruidFernando, Nilisha, u4672578en_AU
local.description.notesImported from ARIESen_AU
local.identifier.absfor000000 - Internal ANU use onlyen_AU
local.identifier.ariespublicationu3102795xPUB4707en_AU
local.identifier.citationvolume10en_AU
local.identifier.doi10.3389/fimmu.2019.01618en_AU
local.identifier.thomsonIDWOS:000475823800001
local.publisher.urlhttps://www.frontiersin.org/en_AU
local.type.statusPublished Versionen_AU

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