Pioglitazone acutely reduces energy metabolism and insulin secretion in rats

Lamontagne, Julien; Jalbert-Arsenault, Élise; Pepin, Emilie; Peyot, Marie-Line; Ruderman, Neil; Nolan, Christopher; Joly, Erik; Madiraju, Murthy S R; Poitout, Vincent; Prentki, Marc

Pioglitazone acutely reduces energy metabolism and insulin secretion in rats

Date

2013

Authors

Lamontagne, Julien

Jalbert-Arsenault, Élise

Pepin, Emilie

Peyot, Marie-Line

Ruderman, Neil

Nolan, Christopher

Joly, Erik

Madiraju, Murthy S R

Poitout, Vincent

Prentki, Marc

Publisher

American Diabetes Association

Abstract

Our objective was to determine if the insulin-sensitizing drug pioglitazone acutely reduces insulin secretion and causes metabolic deceleration in vivo independently of change in insulin sensitivity. We assessed glucose homeostasis by hyperinsulinemiceugl