Antiangiogenic activity of sophorolipids extracted from refined bleached deodorized palm olein

dc.contributor.authorMohamed, Shazmin Kithur
dc.contributor.authorAsif, Muhammad
dc.contributor.authorNazari, Mansoureh Vishkaei
dc.contributor.authorBaharetha, Hussein M.
dc.contributor.authorMahmood, Syed
dc.contributor.authorYatim, Abdul Rashid M.
dc.contributor.authorAbdul Majid, Aman Shah
dc.contributor.authorAbdul Majid, Amin Malik Shah Bin
dc.date.accessioned2019-12-18T05:04:06Z
dc.date.available2019-12-18T05:04:06Z
dc.date.issued2019-03-19
dc.date.updated2019-08-04T08:18:23Z
dc.description.abstractOBJECTIVES: Sophorolipids (SLs) are a group of surface-active glycolipids produced by a type of nonpathogenic yeast Candida bombicola in the presence of vegetable oil through fermentation technology. SLs have shown antitumor activity; however, the mechanism of action underlying the anticancer activity of SLs is poorly understood. This work evaluated the anticancer activity of SLs fermented from palm oil by exploring its antiangiogenic activity. MATERIALS AND METHODS: The SLs that were fermented and further characterized for their biochemical activities. Cytotoxicity study was performed to assess cytostatic properties. A series of in vitro and ex vivo angiogenesis assay was also carried out. The relative fold change in the expression of p53 mRNA by SLs was also studied. RESULTS: Altogether, the data show that SLs derived from palm oil fermentation process inhibited neovascularization in the ex vivo tissue segments and also the endothelial cell proliferation between 50% and 65% inhibition as a whole. The palm oil derived SLs also caused downregulation of the suppression level of vascular endothelial growth factor and also upregulate the p53 mRNA level. The analytical studies revealed the presence of high amount of phenolic compounds but with relatively weak antioxidant activity. The gas chromatography-mass spectrometry studies revealed abundant amount of palmitic and oleic acid, the latter an established antiangiogenic agent, and the former being proangiogenic. CONCLUSION: Therefore, it can be concluded from this study that SLs derived from fermented palm oil have potent antiangiogenic activity which may be attributed by its oleic acid component.en_AU
dc.description.sponsorshipWe also gratefully acknowledge the financial support from the Ministry of Agriculture (MoA), Malaysia, under NKEA Research Grant Scheme; grant number: 304/PFARMASI/650735/K123 and 304/PFARMASI/650737/K123.en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.citationKithur Mohamed S, Asif M, Nazari MV, Baharetha HM, Mahmood S, Yatim AR, et al. Antiangiogenic activity of sophorolipids extracted from refined bleached deodorized palm olein. Indian J Pharmacol 2019;51:45-54.en_AU
dc.identifier.issn0253-7613en_AU
dc.identifier.urihttp://hdl.handle.net/1885/195766
dc.language.isoen_AUen_AU
dc.provenanceThis is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution‑NonCommercial‑ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non‑commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.en_AU
dc.publisherMedknow Publicationsen_AU
dc.rights© 2019 Indian Journal of Pharmacologyen_AU
dc.rights.licenseCreative Commons Attribution‑NonCommercial‑ShareAlike 4.0 Licenseen_AU
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/en_AU
dc.sourceIndian Journal of Pharmacologyen_AU
dc.subjectAntiangiogenicen_AU
dc.subjectanticanceren_AU
dc.subjectfermentationen_AU
dc.subjectpalm oilen_AU
dc.subjectsophorolipidsen_AU
dc.titleAntiangiogenic activity of sophorolipids extracted from refined bleached deodorized palm oleinen_AU
dc.typeJournal articleen_AU
dcterms.accessRightsOpen Accessen_AU
dcterms.dateAccepted2019-03-04
local.bibliographicCitation.issue1en_AU
local.bibliographicCitation.lastpage54en_AU
local.bibliographicCitation.startpage45en_AU
local.contributor.affiliationMohamed, Shazmin Kithur, Universti Sains Malaysiaen_AU
local.contributor.affiliationAsif, Muhammad, Universti Sains Malaysiaen_AU
local.contributor.affiliationNazari, Mansoureh Vishkaei, Universiti Sains Malaysiaen_AU
local.contributor.affiliationBaharetha, Hussein M., Universiti Sains Malaysiaen_AU
local.contributor.affiliationMahmood, Syed, University Malaysia Pahangen_AU
local.contributor.affiliationYatim, Abdul Rashid M., Malaysian Palm Oil Boarden_AU
local.contributor.affiliationAbdul Majid, Aman Shah, Quest International Universityen_AU
local.contributor.affiliationAbdul Majid, Amin Malik Shah Bin, College of Health and Medicine, ANUen_AU
local.contributor.authoremailu1026638@anu.edu.auen_AU
local.contributor.authoruidAbdul Majid, Amin Malik Shah Bin, u1026638en_AU
local.description.notesImported from ARIESen_AU
local.identifier.absfor111200 - ONCOLOGY AND CARCINOGENESISen_AU
local.identifier.absseo860803 - Human Pharmaceutical Treatments (e.g. Antibiotics)en_AU
local.identifier.ariespublicationu3102795xPUB1150en_AU
local.identifier.citationvolume51en_AU
local.identifier.doi10.4103/ijp.IJP_312_18en_AU
local.identifier.scopusID2-s2.0-85063522209
local.identifier.uidSubmittedByu3102795en_AU
local.publisher.urlhttp://www.ijp-online.comen_AU
local.type.statusPublished Versionen_AU

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