Antiangiogenic activity of sophorolipids extracted from refined bleached deodorized palm olein
dc.contributor.author | Mohamed, Shazmin Kithur | |
dc.contributor.author | Asif, Muhammad | |
dc.contributor.author | Nazari, Mansoureh Vishkaei | |
dc.contributor.author | Baharetha, Hussein M. | |
dc.contributor.author | Mahmood, Syed | |
dc.contributor.author | Yatim, Abdul Rashid M. | |
dc.contributor.author | Abdul Majid, Aman Shah | |
dc.contributor.author | Abdul Majid, Amin Malik Shah Bin | |
dc.date.accessioned | 2019-12-18T05:04:06Z | |
dc.date.available | 2019-12-18T05:04:06Z | |
dc.date.issued | 2019-03-19 | |
dc.date.updated | 2019-08-04T08:18:23Z | |
dc.description.abstract | OBJECTIVES: Sophorolipids (SLs) are a group of surface-active glycolipids produced by a type of nonpathogenic yeast Candida bombicola in the presence of vegetable oil through fermentation technology. SLs have shown antitumor activity; however, the mechanism of action underlying the anticancer activity of SLs is poorly understood. This work evaluated the anticancer activity of SLs fermented from palm oil by exploring its antiangiogenic activity. MATERIALS AND METHODS: The SLs that were fermented and further characterized for their biochemical activities. Cytotoxicity study was performed to assess cytostatic properties. A series of in vitro and ex vivo angiogenesis assay was also carried out. The relative fold change in the expression of p53 mRNA by SLs was also studied. RESULTS: Altogether, the data show that SLs derived from palm oil fermentation process inhibited neovascularization in the ex vivo tissue segments and also the endothelial cell proliferation between 50% and 65% inhibition as a whole. The palm oil derived SLs also caused downregulation of the suppression level of vascular endothelial growth factor and also upregulate the p53 mRNA level. The analytical studies revealed the presence of high amount of phenolic compounds but with relatively weak antioxidant activity. The gas chromatography-mass spectrometry studies revealed abundant amount of palmitic and oleic acid, the latter an established antiangiogenic agent, and the former being proangiogenic. CONCLUSION: Therefore, it can be concluded from this study that SLs derived from fermented palm oil have potent antiangiogenic activity which may be attributed by its oleic acid component. | en_AU |
dc.description.sponsorship | We also gratefully acknowledge the financial support from the Ministry of Agriculture (MoA), Malaysia, under NKEA Research Grant Scheme; grant number: 304/PFARMASI/650735/K123 and 304/PFARMASI/650737/K123. | en_AU |
dc.format.mimetype | application/pdf | en_AU |
dc.identifier.citation | Kithur Mohamed S, Asif M, Nazari MV, Baharetha HM, Mahmood S, Yatim AR, et al. Antiangiogenic activity of sophorolipids extracted from refined bleached deodorized palm olein. Indian J Pharmacol 2019;51:45-54. | en_AU |
dc.identifier.issn | 0253-7613 | en_AU |
dc.identifier.uri | http://hdl.handle.net/1885/195766 | |
dc.language.iso | en_AU | en_AU |
dc.provenance | This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution‑NonCommercial‑ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non‑commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. | en_AU |
dc.publisher | Medknow Publications | en_AU |
dc.rights | © 2019 Indian Journal of Pharmacology | en_AU |
dc.rights.license | Creative Commons Attribution‑NonCommercial‑ShareAlike 4.0 License | en_AU |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0/ | en_AU |
dc.source | Indian Journal of Pharmacology | en_AU |
dc.subject | Antiangiogenic | en_AU |
dc.subject | anticancer | en_AU |
dc.subject | fermentation | en_AU |
dc.subject | palm oil | en_AU |
dc.subject | sophorolipids | en_AU |
dc.title | Antiangiogenic activity of sophorolipids extracted from refined bleached deodorized palm olein | en_AU |
dc.type | Journal article | en_AU |
dcterms.accessRights | Open Access | en_AU |
dcterms.dateAccepted | 2019-03-04 | |
local.bibliographicCitation.issue | 1 | en_AU |
local.bibliographicCitation.lastpage | 54 | en_AU |
local.bibliographicCitation.startpage | 45 | en_AU |
local.contributor.affiliation | Mohamed, Shazmin Kithur, Universti Sains Malaysia | en_AU |
local.contributor.affiliation | Asif, Muhammad, Universti Sains Malaysia | en_AU |
local.contributor.affiliation | Nazari, Mansoureh Vishkaei, Universiti Sains Malaysia | en_AU |
local.contributor.affiliation | Baharetha, Hussein M., Universiti Sains Malaysia | en_AU |
local.contributor.affiliation | Mahmood, Syed, University Malaysia Pahang | en_AU |
local.contributor.affiliation | Yatim, Abdul Rashid M., Malaysian Palm Oil Board | en_AU |
local.contributor.affiliation | Abdul Majid, Aman Shah, Quest International University | en_AU |
local.contributor.affiliation | Abdul Majid, Amin Malik Shah Bin, College of Health and Medicine, ANU | en_AU |
local.contributor.authoremail | u1026638@anu.edu.au | en_AU |
local.contributor.authoruid | Abdul Majid, Amin Malik Shah Bin, u1026638 | en_AU |
local.description.notes | Imported from ARIES | en_AU |
local.identifier.absfor | 111200 - ONCOLOGY AND CARCINOGENESIS | en_AU |
local.identifier.absseo | 860803 - Human Pharmaceutical Treatments (e.g. Antibiotics) | en_AU |
local.identifier.ariespublication | u3102795xPUB1150 | en_AU |
local.identifier.citationvolume | 51 | en_AU |
local.identifier.doi | 10.4103/ijp.IJP_312_18 | en_AU |
local.identifier.scopusID | 2-s2.0-85063522209 | |
local.identifier.uidSubmittedBy | u3102795 | en_AU |
local.publisher.url | http://www.ijp-online.com | en_AU |
local.type.status | Published Version | en_AU |
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