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Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome

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dc.contributor.authorFox, Daniel
dc.contributor.authorMathur, Anukriti
dc.contributor.authorXue, Yansong
dc.contributor.authorLiu, Yunqi
dc.contributor.authorTan, Wei Hong
dc.contributor.authorFeng, Shouya
dc.contributor.authorPandey, Abhimanu
dc.contributor.authorNgo, Chinh
dc.contributor.authorHayward, Jenni
dc.contributor.authorAtmosukarto, Ines
dc.contributor.authorPrice, Jason
dc.contributor.authorjohnson, matthew
dc.contributor.authorJessberger, Nadja
dc.contributor.authorRobertson, Avril
dc.contributor.authorBurgio, Gaetan
dc.contributor.authorTscharke, David
dc.contributor.authorFox, Edward M
dc.contributor.authorLeyton, Denisse
dc.contributor.authorKaakoush, Nadeem
dc.contributor.authorMärtlbauer, Erwin
dc.contributor.authorLeppla, Stephen H
dc.contributor.authorMan, Si Ming
dc.date.accessioned2021-01-19T02:24:24Z
dc.date.available2021-01-19T02:24:24Z
dc.date.issued2020
dc.date.updated2020-11-02T04:19:33Z
dc.description.abstractInflammasomes are important for host defence against pathogens and homeostasis with commensal microbes. Here, we show non-haemolytic enterotoxin (NHE) from the neglected human foodborne pathogen Bacillus cereus is an activator of the NLRP3 inflammasome and pyroptosis. NHE is a non-redundant toxin to haemolysin BL (HBL) despite having a similar mechanism of action. Via a putative transmembrane region, subunit C of NHE initiates binding to the plasma membrane, leading to the recruitment of subunit B and subunit A, thus forming a tripartite lytic pore that is permissive to efflux of potassium. NHE mediates killing of cells from multiple lineages and hosts, highlighting a versatile functional repertoire in different host species. These data indicate that NHE and HBL operate synergistically to induce inflammation and show that multiple virulence factors from the same pathogen with conserved function and mechanism of action can be exploited for sensing by a single inflammasome.en_AU
dc.description.sponsorshipD.F. is supported by an Australian Government Research Training Program (RTP) Scholarship and a John Curtin School of Medical Research Gordon Ada Scholarship. A.M., S.F. and A.P. are supported by a John Curtin School of Medical Research International Ph.D. scholarship. W.H.T. is supported by a Terrell International Undergraduate Scholarship from the Australian National University. G.B. is supported by the National Collaborative Research Infrastructure Strategy (NCRIS) via the Australian Phenomics Network, the National Health and Medical Research Council of Australia under project grant (APP1143008), the Australian Research Council (Discover Project DP180101494) and the National Natural Science Foundation of China (under the project 81772214). D.C.T. is supported by the National Health and Medical Research Council of Australia (under Project Grants APP1084283 and APP1126599 and Senior Research Fellowship APP1104329) and the Australian Research Council (under Discover Project DP190101325). D.L.L. is supported by an Australian Research Council Future Fellowship (FT150100452). N.O.K. is supported by a Career Development Fellowship from the Cancer Institute NSW (15/CDF/1-11) and a UNSW Scientia Fellowship. S.H.L. is supported, in part, by the Intramural Program of the National Institute of Allergy and Infectious Diseases, NIH, USA. S.M.M. is supported by the Australian National University, The Gretel and Gordon Bootes Medical Research Foundation, and the National Health and Medical Research Council of Australia under Project Grants (APP1141504, APP1146864, APP1162103, and APP1163358) and the R.D. Wright Career Development Fellowship (APP1162025).en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn2041-1723en_AU
dc.identifier.urihttp://hdl.handle.net/1885/219762
dc.language.isoen_AUen_AU
dc.provenanceThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en_AU
dc.publisherMacmillan Publishers Ltden_AU
dc.relationhttp://purl.org/au-research/grants/nhmrc/1143008en_AU
dc.relationhttp://purl.org/au-research/grants/arc/DP180101494en_AU
dc.relationhttp://purl.org/au-research/grants/nhmrc/1084283en_AU
dc.relationhttp://purl.org/au-research/grants/nhmrc/1104329en_AU
dc.relationhttp://purl.org/au-research/grants/arc/DP190101325en_AU
dc.relationhttp://purl.org/au-research/grants/arc/FT150100452en_AU
dc.relationhttp://purl.org/au-research/grants/nhmrc/1141504en_AU
dc.relationhttp://purl.org/au-research/grants/nhmrc/1146864en_AU
dc.rights© The Author(s) 2020en_AU
dc.rights.licenseCreative Commons Attribution 4.0 International Licenseen_AU
dc.rights.urihttp://creativecommons.org/ licenses/by/4.0/en_AU
dc.sourceNature Communicationsen_AU
dc.titleBacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasomeen_AU
dc.typeJournal articleen_AU
dcterms.accessRightsOpen Accessen_AU
local.bibliographicCitation.issue760en_AU
local.bibliographicCitation.lastpage16en_AU
local.bibliographicCitation.startpage1en_AU
local.contributor.affiliationFox, Daniel, College of Health and Medicine, ANUen_AU
local.contributor.affiliationMathur, Anukriti, College of Health and Medicine, ANUen_AU
local.contributor.affiliationXue, Yansong, College of Health and Medicine, ANUen_AU
local.contributor.affiliationLiu, Yunqi, College of Health and Medicine, ANUen_AU
local.contributor.affiliationTan, Wei Hong, College of Health and Medicine, ANUen_AU
local.contributor.affiliationFeng, Shouya, College of Health and Medicine, ANUen_AU
local.contributor.affiliationPandey, Abhimanu, College of Health and Medicine, ANUen_AU
local.contributor.affiliationNgo, Chinh, College of Health and Medicine, ANUen_AU
local.contributor.affiliationHayward, Jenni, College of Health and Medicine, ANUen_AU
local.contributor.affiliationAtmosukarto, Ines, Non-ANU institution, Lipoteken_AU
local.contributor.affiliationPrice, Jason, Non-ANU institution, Lipoteken_AU
local.contributor.affiliationJohnson, Matthew, College of Science, ANUen_AU
local.contributor.affiliationJessberger, Nadja, Ludwig-Maximilians-Universität Münchenen_AU
local.contributor.affiliationRobertson, Avril, University of Queenslanden_AU
local.contributor.affiliationBurgio, Gaetan, College of Health and Medicine, ANUen_AU
local.contributor.affiliationTscharke, David, College of Health and Medicine, ANUen_AU
local.contributor.affiliationFox, Edward M, Commonwealth Scientific and Industrial Research Organisation (CSIRO) Agriculture and Fooden_AU
local.contributor.affiliationLeyton, Denisse, College of Science, ANUen_AU
local.contributor.affiliationKaakoush, Nadeem, UNSWen_AU
local.contributor.affiliationMärtlbauer, Erwin, Ludwig-Maximilians-Universität Münchenen_AU
local.contributor.affiliationLeppla, Stephen H, National Institutes of Healthen_AU
local.contributor.affiliationMan, Si Ming, College of Health and Medicine, ANUen_AU
local.contributor.authoruidFox, Daniel, u5563010en_AU
local.contributor.authoruidMathur, Anukriti, u6318683en_AU
local.contributor.authoruidXue, Yansong, u1063573en_AU
local.contributor.authoruidLiu, Yunqi, u1061819en_AU
local.contributor.authoruidTan, Wei Hong, u6316487en_AU
local.contributor.authoruidFeng, Shouya, u1043633en_AU
local.contributor.authoruidPandey, Abhimanu, u6566970en_AU
local.contributor.authoruidNgo, Chinh, u1045931en_AU
local.contributor.authoruidHayward, Jenni, u1043494en_AU
local.contributor.authoruidAtmosukarto, Ines, u3881315en_AU
local.contributor.authoruidPrice, Jason, u4884728en_AU
local.contributor.authoruidJohnson, Matthew, u1030954en_AU
local.contributor.authoruidBurgio, Gaetan, u5727247en_AU
local.contributor.authoruidTscharke, David, u4334102en_AU
local.contributor.authoruidLeyton, Denisse, u1003452en_AU
local.contributor.authoruidMan, Si Ming, u1036742en_AU
local.description.notesImported from ARIESen_AU
local.identifier.absfor110707 - Innate Immunityen_AU
local.identifier.absseo920108 - Immune System and Allergyen_AU
local.identifier.ariespublicationu1036742xPUB50en_AU
local.identifier.citationvolume11en_AU
local.identifier.doi10.1038/s41467-020-14534-3en_AU
local.publisher.urlhttp://www.nature.com/ncomms/index.htmlen_AU
local.type.statusPublished Versionen_AU

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