3,4'-Linked bis(piperidines) related to the haliclonacyclamine class of marine alkaloids: synthesis using crossed-aldol chemistry and preliminary biological evaluations

Banwell, Martin; Coster, Mark; Hungerford, Natasha; Garson, Mary J; Su, Stephen; Kotze, Andrew; Munro, Murray HG

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3,4'-Linked bis(piperidines) related to the haliclonacyclamine class of marine alkaloids: synthesis using crossed-aldol chemistry and preliminary biological evaluations

Date

2012

Authors

Banwell, Martin

Coster, Mark

Hungerford, Natasha

Garson, Mary J

Su, Stephen

Kotze, Andrew

Munro, Murray HG

Publisher

Royal Society of Chemistry

Abstract

Compounds 2-5, incorporating various elements of the 3,4′- bis(piperidine) core associated with the sponge-derived alkaloid haliclonacyclamine A (HA, 1), have been prepared through, inter alia, aldol-type reactions of N-substituted piperidin-4-ones and