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Estimating protective vaccine efficacy from large trials with recruitment

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dc.contributor.authorBecker, Niels
dc.contributor.authorLefevre, Claude
dc.contributor.authorUtev, Sergey
dc.date.accessioned2015-12-07T22:22:43Z
dc.date.issued2007
dc.date.updated2015-12-07T09:08:18Z
dc.description.abstractVaccine response is often random because of possible vaccine failures and variation in the immune systems of hosts. A concept of protective vaccine efficacy is defined as the mean vaccine ability to reduce individual susceptibilities to infection. The problem under study is how to measure this efficacy from data on a large vaccine trial in which participants are recruited over a period of time. First, lower and upper bounds are derived that apply for all types of protection induced by the vaccine. Then, the lower bound is shown to be a good estimator under certain conditions usually met in practice.
dc.identifier.issn0378-3758
dc.identifier.urihttp://hdl.handle.net/1885/20355
dc.publisherElsevier
dc.sourceJournal of Statistical Planning and Inference
dc.subjectKeywords: Asymptotic distribution; Estimation; Lower and upper bounds; Random vaccine response; Recruiting trial participants
dc.titleEstimating protective vaccine efficacy from large trials with recruitment
dc.typeJournal article
local.bibliographicCitation.issue3
local.bibliographicCitation.lastpage914
local.bibliographicCitation.startpage907
local.contributor.affiliationBecker, Niels, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationLefevre, Claude, Universite Libre de Bruxelles
local.contributor.affiliationUtev, Sergey, University of Nottingham
local.contributor.authoruidBecker, Niels, u9707783
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor111706 - Epidemiology
local.identifier.ariespublicationu4054856xPUB12
local.identifier.citationvolume137
local.identifier.doi10.1016/j.jspi.2006.06.016
local.identifier.scopusID2-s2.0-33750555804
local.type.statusPublished Version

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