Unravelling the evolutionary origins of X chromosome inactivation in mammals: insights from marsupials and monotremes

Date

2009

Authors

Deakin, Janine
Chaumeil, Julie
Hore, Tim
Graves, Jennifer

Journal Title

Journal ISSN

Volume Title

Publisher

Kluwer Academic Publishers

Abstract

Determining the evolutionary origin of X inactivation mechanisms in mammals requires knowledge of features of X inactivation across all three major mammal lineages; monotremes, marsupials and eutherians. In the past, research into X inactivation in marsupials and monotremes lagged far behind the major advances made in understanding the mechanisms of X inactivation in human and mouse. Fragmentary knowledge of the genic content and sequence of marsupial and monotreme X chromosomes has been alleviated by the recent release of genome sequences for two marsupials and one monotreme. This has lead to a number of important findings, among which is the absence of XIST in marsupials and monotremes, and the surprising finding that X-borne genes in platypus are subject to stochastic transcriptional inhibition rather than whole chromosome inactivation. Availability of sequence data, and new techniques for studying expression and chromatin modification, now make rapid advance possible.

Description

Keywords

Keywords: ATR protein; BRCA1 associated ring domain protein 1; heterochromatin protein 1; protein msci; unclassified drug; chromatin structure; CpG island; epigenetics; gene expression; gene expression regulation; genome imprinting; mammal; marsupial; monotremate; Dosage compensation; Marsupial; Monotreme; X chromosome inactivation

Citation

Source

Chromosome Research

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1007/s10577-009-9058-6

Restricted until

2037-12-31