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The loop between helix 4 and helix 5 in the monocarboxylate transporter MCT1 is important for substrate selection and protein stability

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Date

2003

Authors

Galic, S
Schneider, Hans-Peter
Broer, Angelika
Deitmer, Joachim W
Broer, Stefan

Journal Title

Journal ISSN

Volume Title

Publisher

Portland Press

Abstract

Transport of lactate, pyruvate and the ketone bodies acetoacetate and β-hydroxybutyrate, is mediated in most mammalian cells by members of the monocarboxylate transporter family (SLC16). A conserved signature sequence has been identified in this family,

Description

Keywords

Keywords: Acetone; Biological membranes; Ketones; Lactate; Stereochemistry; 3 hydroxybutyric acid; acetoacetic acid; glutamine; ketone body; lactic acid; monocarboxylate transporter; pyruvic acid; animal cell; article; enzyme substrate; immunoblotting; mutation; no Monocarboxylate transporter (MCT1); Stereospecificity; Structure-function relationship; Transport mechanism

Citation

URI

http://hdl.handle.net/1885/88566

Collections

ANU Research Publications

Source

Biochemical Journal

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1042/BJ20030799

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