A dihydropyridine receptor alpha(1s) loop region critical for skeletal muscle contraction is intrinsically unstructured and binds to a SPRY domain of the type 1 ryanodine receptor

Cui, Yan Fang; Tae, Han Shen; Norris, Nicole; Karunasekara, Yamuna; Pouliquin, Pierre; Board, Philip; Dulhunty, Angela; Casarotto, Marco

A dihydropyridine receptor alpha(1s) loop region critical for skeletal muscle contraction is intrinsically unstructured and binds to a SPRY domain of the type 1 ryanodine receptor

Date

2009

Authors

Cui, Yan Fang

Tae, Han Shen

Norris, Nicole

Karunasekara, Yamuna

Pouliquin, Pierre

Board, Philip

Dulhunty, Angela

Casarotto, Marco

Publisher

Pergamon-Elsevier Ltd

Abstract

The II-III loop of the dihydropyridine receptor (DHPR) α1s subunit is a modulator of the ryanodine receptor (RyR1) Ca2+ release channel in vitro and is essential for skeletal muscle contraction in vivo. Despite its importance, the structure of this loop