A dihydropyridine receptor alpha(1s) loop region critical for skeletal muscle contraction is intrinsically unstructured and binds to a SPRY domain of the type 1 ryanodine receptor
Date
2009
Authors
Cui, Yan Fang
Tae, Han Shen
Norris, Nicole
Karunasekara, Yamuna
Pouliquin, Pierre
Board, Philip
Dulhunty, Angela
Casarotto, Marco
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Publisher
Pergamon-Elsevier Ltd
Abstract
The II-III loop of the dihydropyridine receptor (DHPR) α1s subunit is a modulator of the ryanodine receptor (RyR1) Ca2+ release channel in vitro and is essential for skeletal muscle contraction in vivo. Despite its importance, the structure of this loop
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Keywords
Keywords: 1,4 dihydropyridine receptor; 1,4 dihydropyridine receptor alpha 1s; calcium ion; ryanodine receptor 1; sprouty protein; unclassified drug; calcium channel L type; chimeric protein; membrane protein; phosphoprotein; ryanodine receptor; SPRY1 protein, huma DHPR; Intrinsically unstructured protein; NMR; Protein-protein interaction; RyR
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Source
The International Journal of Biochemistry and Cell Biology
Type
Journal article
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2037-12-31
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