Cardiac ryanodine receptor activation by a high Ca2+ store load is reversed in a reducing cytoplasmic redox environment

Hanna, Amy; Lam, Alex; Thekkedam, Chris; Gallant, Esther; Beard, Nicole; Dulhunty, Angela

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Cardiac ryanodine receptor activation by a high Ca2+ store load is reversed in a reducing cytoplasmic redox environment

Date

2014

Authors

Hanna, Amy

Lam, Alex

Thekkedam, Chris

Gallant, Esther

Beard, Nicole

Dulhunty, Angela

Publisher

The Company of Biologists Ltd

Abstract

Here, we report the impact of redox potential on isolated cardiac ryanodine receptor (RyR2) channel activity and its response to physiological changes in luminal [Ca2+]. Basal leak from the sarcoplasmic reticulum is required for normal Ca2+ handling, but