Inflammasomes in the gastrointestinal tract: infection, cancer and gut microbiota homeostasis

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dc.contributor.authorMan, Si Ming
dc.date.accessioned2019-07-12T05:00:59Z
dc.date.issued2018
dc.date.updated2019-03-31T07:19:26Z
dc.description.abstractInflammasome signalling is an emerging pillar of innate immunity and has a central role in the regulation of gastrointestinal health and disease. Activation of the inflammasome complex mediates both the release of the pro-inflammatory cytokines IL-1β and IL-18 and the execution of a form of inflammatory cell death known as pyroptosis. In most cases, these mediators of inflammation provide protection against bacterial, viral and protozoal infections. However, unchecked inflammasome activities perpetuate chronic inflammation, which underpins the molecular and pathophysiological basis of gastritis, IBD, upper and lower gastrointestinal cancer, nonalcoholic fatty liver disease and obesity. Studies have also highlighted an inflammasome signature in the maintenance of gut microbiota and gut-brain homeostasis. Harnessing the immunomodulatory properties of the inflammasome could transform clinical practice in the treatment of acute and chronic gastrointestinal and extragastrointestinal diseases. This Review presents an overview of inflammasome biology in gastrointestinal health and disease and describes the value of experimental and pharmacological intervention in the treatment of inflammasome-associated clinical manifestations.en_AU
dc.description.sponsorshipS.M.M. is supported by the Australian National University Futures Award, The Gretel and Gordon Bootes Medical Research Foundation and the National Health and Medical Research Council of Australia under project grants (APP1141504 and APP1146864) and the R.G. Menzies Early Career Fellowship (APP1091544).en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn1759-5045en_AU
dc.identifier.urihttp://hdl.handle.net/1885/164559
dc.language.isoen_AUen_AU
dc.publisherNature Publishing Groupen_AU
dc.relationhttp://purl.org/au-research/grants/nhmrc/1141504en_AU
dc.relationhttp://purl.org/au-research/grants/nhmrc/1146864en_AU
dc.relationhttp://purl.org/au-research/grants/nhmrc/1091544en_AU
dc.rights© 2018en_AU
dc.sourceNature Reviews. Gastroenterology & Hepatologyen_AU
dc.titleInflammasomes in the gastrointestinal tract: infection, cancer and gut microbiota homeostasisen_AU
dc.typeJournal articleen_AU
local.bibliographicCitation.issue12en_AU
local.bibliographicCitation.lastpage737en_AU
local.bibliographicCitation.startpage721en_AU
local.contributor.affiliationMan, Si Ming, College of Health and Medicine, ANUen_AU
local.contributor.authoremailu1036742@anu.edu.auen_AU
local.contributor.authoruidMan, Si Ming, u1036742en_AU
local.description.embargo2037-12-31
local.description.notesImported from ARIESen_AU
local.identifier.absfor110707 - Innate Immunityen_AU
local.identifier.absseo920108 - Immune System and Allergyen_AU
local.identifier.ariespublicationu1036742xPUB44en_AU
local.identifier.citationvolume15en_AU
local.identifier.doi10.1038/s41575-018-0054-1en_AU
local.identifier.scopusID2-s2.0-85053386248
local.identifier.uidSubmittedByu1036742en_AU
local.publisher.urlhttps://www.nature.com/en_AU
local.type.statusPublished Versionen_AU

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