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Single nucleotide variants (SNVs) define senescence-accelerated SAMP8 mice, a model of a geriatric condition

Date

Authors

Delerue, Fabien

Sjollema, Geoffrey

Whittle, Belinda

Kruger, Sarah

Andrews, Dan

Gotz, Jurgen

Publisher

Hindawi Publishing Corporation

Abstract

One of the major challenges in neurodegenerative research is modeling systemic aging. Here, senescence-accelerated mice such as the multigenic SAMP8 (senescence accelerated prone 8) mice are useful as they are characterized by an early manifestation of se

Keywords

Keywords: aging; Alzheimer disease; animal experiment; animal model; animal tissue; article; brain dysfunction; controlled study; exome; gene mutation; gene sequence; genotype; immune dysregulation; lifespan; mouse; nerve degeneration; nonhuman; phenotype; priority Alzheimer's disease; exome sequencing; mouse; senescence; sequence nucleotide variants

URI

http://hdl.handle.net/1885/73208

Collections

ANU Research Publications

Source

International Journal of Alzheimer's Disease

Type

Journal article

Access Statement

Open Access

DOI

10.3233/JAD-130089

Downloads

File

Description

01_Delerue_Single_nucleotide_variants_2013.pdf (413.34 KB)