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The effect of β-sheet breaker peptides on metal associated Amyloid-β peptide aggregation process

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dc.contributor.authorStellato, F
dc.contributor.authorFusco, Zelio
dc.contributor.authorChiaraluce, R
dc.contributor.authorConsalvi, V
dc.contributor.authorDinarelli, S
dc.contributor.authorPlacidi, E
dc.contributor.authorPetrosino, M
dc.contributor.authorRossi, G C
dc.contributor.authorMinicozzi, V
dc.contributor.authorMorante, S
dc.date.accessioned2020-04-06T02:05:42Z
dc.date.issued2017-10
dc.date.updated2019-11-25T07:50:10Z
dc.description.abstractFar-UV Circular Dichroism experiments and Atomic Force Microscopy tomography are employed to assess the impact of beta-sheet breakers on the A beta(1-40) peptide aggregation process in the presence of Cu2+ or Zn2+ transition metals. In this work we focus on two specific 5-amino acids long beta-sheet breakers, namely the LPFFD Soto peptide, already known in the literature, and the LPFFN peptide recently designed and studied by our team. We provide evidence that both 13 -sheet breakers are effective in reducing the A beta(1-40) aggregation propensity, even in the presence of metal ions.en_AU
dc.format.extent5 pagesen_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn0301-4622en_AU
dc.identifier.urihttp://hdl.handle.net/1885/202749
dc.language.isoen_AUen_AU
dc.publisherElsevieren_AU
dc.rights© 2017 Elsevier B.V.en_AU
dc.sourceBiophysical Chemistryen_AU
dc.subjectAmyloid-β peptide, Fibrils, Atomic Force Microscopy, Circular Dichroism, Metal ions, Inhibitoren_AU
dc.titleThe effect of β-sheet breaker peptides on metal associated Amyloid-β peptide aggregation processen_AU
dc.typeJournal articleen_AU
dcterms.dateAccepted2017-05-11
local.bibliographicCitation.lastpage114en_AU
local.bibliographicCitation.startpage110en_AU
local.contributor.affiliationStellato, F, University of Rome Tor Vergataen_AU
local.contributor.affiliationFusco, Zelio, College of Engineering and Computer Science, The Australian National Universityen_AU
local.contributor.affiliationChiaraluce, R, Sapienza University of Romeen_AU
local.contributor.affiliationConsalvi, V, Sapienza University of Romeen_AU
local.contributor.affiliationDinarelli, S, Istituto di Struttura della Materia, CNRen_AU
local.contributor.affiliationPlacidi, E, University of Rome Tor Vergataen_AU
local.contributor.affiliationPetrosino, M, Sapienza University of Romeen_AU
local.contributor.affiliationRossi, G C, University of Rome Tor Vergataen_AU
local.contributor.affiliationMinicozzi, V, University of Rome Tor Vergataen_AU
local.contributor.affiliationMorante, S, University of Rome Tor Vergataen_AU
local.contributor.authoruidFusco, Zelio, u6091110en_AU
local.description.embargo2037-12-31
local.description.notesImported from ARIESen_AU
local.identifier.absfor029901 - Biological Physicsen_AU
local.identifier.absfor029903 - Medical Physicsen_AU
local.identifier.absseo920112 - Neurodegenerative Disorders Related to Ageingen_AU
local.identifier.ariespublicationu4485658xPUB1030en_AU
local.identifier.citationvolume229en_AU
local.identifier.doi10.1016/j.bpc.2017.05.005en_AU
local.identifier.essn1873-4200en_AU
local.identifier.scopusID2-s2.0-85019577254
local.identifier.thomsonID000413281300016
local.publisher.urlhttps://www.elsevier.com/en_AU
local.type.statusPublished Versionen_AU

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