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The status of cones in the Rhodopsin Mutant P23H-3 Retina: Light-regulated damage and repair in parallel with rods

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Date

2008

Authors

Chrysostomou, Vicki
Stone, Jonathan
Stowe, Sally
Barnett, Nigel L
Valter (Valter-Kocsi), Krisztina

Journal Title

Journal ISSN

Volume Title

Publisher

Association for Research in Vision and Opthalmology

Abstract

PURPOSE. This study tests whether cones in the rhodopsinmutant transgenic P23H-3 retina are damaged by ambient light and whether subsequent light restriction allows repair of damaged cones. METHODS. P23H-3 rats were raised in scotopic cyclic (12 hours of

Description

Keywords

Keywords: opsin; rhodopsin; opsin; rhodopsin; A wave; animal experiment; animal model; animal tissue; article; B wave; controlled study; dark adaptation; electron microscopy; electroretinography; gene mutation; immunohistochemistry; light; light damage; night visio

Citation

URI

http://hdl.handle.net/1885/58858

Collections

ANU Research Publications

Source

Investigative Ophthalmology and Visual Science

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1167/iovs.07-1158

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