Binding Modes of Two Scorpion Toxins to the Voltage-Gated Potassium Channel Kv1.3 Revealed from Molecular Dynamics

Chen, Rong; Chung, Shin-Ho

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Binding Modes of Two Scorpion Toxins to the Voltage-Gated Potassium Channel Kv1.3 Revealed from Molecular Dynamics

Date

2014

Authors

Chen, Rong

Chung, Shin-Ho

Publisher

Open Access

Abstract

Molecular dynamics (MD) simulations are used to examine the binding modes of two scorpion toxins, margatoxin (MgTx) and hongotoxin (HgTx), to the voltage gated K+ channel, Kv1.3. Using steered MD simulations, we insert either Lys28 or Lys35 of the toxins

URI

http://hdl.handle.net/1885/27996

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ANU Research Publications

Source

Toxins

Type

Journal article

Access Statement

Open Access

DOI

10.3390/toxins6072149

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Binding Modes of Two Scorpion Toxins to the Voltage-Gated Potassium Channel Kv1.3 Revealed from Molecular Dynamics

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