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Evidence That the Coactivator CBP/p300 Is Important for Phenobarbital-Induced but Not Basal Expression of the CYP2H1 Gene

Date

Authors

Dogra, Satish

Tremethick, David

May, Fiona J

Publisher

American Society for Pharmacology and Experimental Therapeutics

Abstract

We have previously identified an upstream 556-bp enhancer domain for the chicken CYP2H1 gene that responds to phenobarbital and binds several transcription factors, including the orphan chicken xenobiotic receptor (CXR). By contrast, the promoter lacks a

Keywords

Keywords: cyclic AMP responsive element binding protein; cytochrome P450; histone deacetylase inhibitor; messenger RNA; phenobarbital; protein p300; trichostatin A; animal cell; article; cell assay; chick embryo; chromatin; controlled study; drug response; embryo;

URI

http://hdl.handle.net/1885/92331

Collections

ANU Research Publications

Source

Molecular Pharmacology

Type

Journal article

DOI

10.1124/mol.63.1.73

Restricted until

2037-12-31

Downloads

File

Description

01_Dogra_Evidence_That_the_Coactivator_2003.pdf (387.61 KB)