BALB/c Alleles for Prkdc and Cdkn2a Interact to Modify Tumor Susceptibility in Trp53+/- Mice

Blackburn, Anneke; Brown, Jennifer S; Naber, Stephen P; Otis, Christopher; Wood, Jeffrey; Jerry, Joseph

BALB/c Alleles for Prkdc and Cdkn2a Interact to Modify Tumor Susceptibility in Trp53+/- Mice

Date

2003

Authors

Blackburn, Anneke

Brown, Jennifer S

Naber, Stephen P

Otis, Christopher

Wood, Jeffrey

Jerry, Joseph

Publisher

American Association for Cancer Research

Abstract

In mice heterozygous for p53 (Trp53+/-), the incidence of mammary tumors varies among strains, with C57BL/6 being resistant and BALB/c being susceptible. Mammary tumor phenotypes were examined in female Trp53+/- F1 mice (C57BL/6 × BALB/c; n = 19) and N2

Keywords

Keywords: DNA dependent protein kinase; adrenal tumor; animal experiment; animal model; animal tissue; article; breast cancer; breast carcinogenesis; cancer susceptibility; CDKN2A gene; controlled study; female; gene; gene frequency; gene isolation; gene locus; gen

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http://hdl.handle.net/1885/94280

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ANU Research Publications

Source

Cancer Research

Type

Journal article

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BALB/c Alleles for Prkdc and Cdkn2a Interact to Modify Tumor Susceptibility in Trp53+/- Mice

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