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BALB/c Alleles for Prkdc and Cdkn2a Interact to Modify Tumor Susceptibility in Trp53+/- Mice

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Blackburn, Anneke
Brown, Jennifer S
Naber, Stephen P
Otis, Christopher
Wood, Jeffrey
Jerry, Joseph

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American Association for Cancer Research

Abstract

In mice heterozygous for p53 (Trp53+/-), the incidence of mammary tumors varies among strains, with C57BL/6 being resistant and BALB/c being susceptible. Mammary tumor phenotypes were examined in female Trp53+/- F1 mice (C57BL/6 × BALB/c; n = 19) and N2

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Cancer Research

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