Is action potential threshold lowest in the axon?

Date

2008

Authors

Kole, Maarten
Stuart, Gregory J

Journal Title

Journal ISSN

Volume Title

Publisher

Nature Publishing Group

Abstract

Action potential threshold is thought to be lowest in the axon, but when measured using conventional techniques, we found that action potential voltage threshold of rat cortical pyramidal neurons was higher in the axon than at other neuronal locations. In contrast, both current threshold and voltage threshold of the isolated somato-dendritic spike were substantially higher at the soma. These data indicate that action potential threshold is indeed lowest in the axon.

Description

Keywords

Keywords: sodium channel; action potential; article; brain cortex; dendrite; nerve cell membrane steady potential; nerve fiber; nonhuman; priority journal; pyramidal nerve cell; rat; spike wave; Action Potentials; Anesthetics, Local; Animals; Axons; Dose-Response R

Citation

Source

Nature Neuroscience

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

Restricted until

2037-12-31