Finite Element Modelling of heat exchange in the stroke-affected brain during therapeutic hypothermia

Simple item page
dc.contributor.authorLillicrap, Thomas
dc.contributor.authorTahtali, Murat
dc.contributor.authorNeely, Andrew
dc.contributor.authorLueck, Christian
dc.contributor.authorWang, X
dc.coverage.spatialAdelaide, SA
dc.date.accessioned2022-06-07T05:21:56Z
dc.date.createdDecember 9-12 2012
dc.date.issued2012
dc.date.updated2021-01-17T07:18:58Z
dc.description.abstractHypothermia is a promising neuroprotectant for the treatment of ischaemic stroke. Current trials of hypothermia rely on cooled blood to reduce the temperature of ischaemic brain tissue. However, since blood flow to the ischaemic brain tissue is compromised, there is likely to be spatial variation in the rate and level of cooling accomplished by cooled blood in this tissue. Finite Element Modelling was used to investigate variation the effectiveness of tissue cooling as a result of spatial variations in cerebral blood flow and cerebral metabolic rate. These factors were found to affect the absolute level of tissue cooling achievable, but not the rate of cooling. This study suggests that pharmaceutical reduction of cerebral metabolic rate may improve the effectiveness of current cooling techniques by minimising spatial variation in brain temperature as a result of impaired blood flow, thereby potentially improving patient outcome.en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.isbn9781922107619en_AU
dc.identifier.urihttp://hdl.handle.net/1885/267191
dc.language.isoen_AUen_AU
dc.publisherEngineers Australiaen_AU
dc.relation.ispartofseries7th Australasian Congress on Applied Mechanics, ACAM 2012en_AU
dc.rights© 2012 Engineers Australiaen_AU
dc.sourceAdvances in Applied Mechanics Research, Conference Proceedings - 7th Australasian Congress on Applied Mechanics, ACAM 2012en_AU
dc.subjectBlooden_AU
dc.subjectBlood vesselsen_AU
dc.subjectBrainen_AU
dc.subjectCoolingen_AU
dc.subjectFinite element methoden_AU
dc.subjectHemodynamicsen_AU
dc.subjectHypothermiaen_AU
dc.subjectMechanicsen_AU
dc.subjectMetabolismen_AU
dc.subjectBrain temperaturesen_AU
dc.subjectCerebral blood flowen_AU
dc.subjectCooling techniqueen_AU
dc.subjectFinite element modellingen_AU
dc.subjectPennes bio-heat equationsen_AU
dc.subjectSpatial variationsen_AU
dc.subjectStrokeen_AU
dc.subjectThe Finite element modellingen_AU
dc.subjectHypothermiaen_AU
dc.subjectPennes bioheat equationen_AU
dc.subjectStrokeen_AU
dc.titleFinite Element Modelling of heat exchange in the stroke-affected brain during therapeutic hypothermiaen_AU
dc.typeConference paperen_AU
local.bibliographicCitation.lastpage667en_AU
local.bibliographicCitation.startpage657en_AU
local.contributor.affiliationLillicrap, Thomas, College of Health and Medicine, ANUen_AU
local.contributor.affiliationTahtali, Murat, University of New South Walesen_AU
local.contributor.affiliationNeely, Andrew, University of New South Walesen_AU
local.contributor.affiliationLueck, Christian, College of Health and Medicine, ANUen_AU
local.contributor.affiliationWang, X, School of Engineering and Information Technologyen_AU
local.contributor.authoremailu1807496@anu.edu.auen_AU
local.contributor.authoruidLillicrap, Thomas, u4128056en_AU
local.contributor.authoruidLueck, Christian, u1807496en_AU
local.description.embargo2099-12-31
local.description.notesImported from ARIESen_AU
local.description.refereedYes
local.identifier.absfor110903 - Central Nervous Systemen_AU
local.identifier.absfor110904 - Neurology and Neuromuscular Diseasesen_AU
local.identifier.absfor110201 - Cardiology (incl. Cardiovascular Diseases)en_AU
local.identifier.ariespublicationU3488905xPUB18847en_AU
local.identifier.scopusID2-s2.0-84907417692
local.identifier.uidSubmittedByU3488905en_AU
local.type.statusPublished Versionen_AU

Downloads

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
01_Lillicrap_Finite_Element_Modelling_of_2012.pdf
Size:
749.62 KB
Format:
Adobe Portable Document Format
Download

Collections

ANU Research Publications

DSpace software copyright © 2002-2024 LYRASIS