Proteomic characterization of human milk fat globule membrane proteins during a 12 month lactation period

dc.contributor.authorLiao, Yalin
dc.contributor.authorAlvarado, Rudy
dc.contributor.authorPhinney, Brett
dc.contributor.authorLonnerdal, Bo
dc.date.accessioned2015-12-13T22:42:02Z
dc.date.issued2011
dc.date.updated2016-02-24T09:34:24Z
dc.description.abstractThe milk fat globule membrane (MFGM) contains proteins which have been implicated in a variety of health benefits. Milk fat globule membrane proteins were isolated from human milk during a 12 month lactation period and subjected to in-solution digestion and liquid chromatography tandem mass spectrometry analysis. Data were pooled, and our results showed that 191 proteins were identified. Relative quantification of the identified MFGM proteins during the course of lactation was performed by label free spectral counting and differentiation expression analysis, which showed some proteins decreasing during the course of lactation whereas some increased or remained at a relatively constant level. The human MFGM proteins are distributed between intracellular, extracellular, and membrane-associated proteins, and they are mainly involved in cell communication and signal transduction, immune function, metabolism and energy production. This study provides more insights into the dynamic composition of human MFGM proteins, which in turn will enhance our understanding of the physiological significance of MFGM proteins.
dc.identifier.issn1535-3893
dc.identifier.urihttp://hdl.handle.net/1885/78783
dc.publisherAmerican Chemical Society
dc.sourceJournal of Proteome Research
dc.subjectKeywords: cell protein; membrane protein; milk fat; milk fat globule membrane protein; unclassified drug; amino acid sequence; article; breast milk; cell communication; energy yield; female; human; immunity; lactation; liquid chromatography; metabolism; normal huma human milk; LC-MS/MS; milk fat globule membrane; protein; proteomics
dc.titleProteomic characterization of human milk fat globule membrane proteins during a 12 month lactation period
dc.typeJournal article
local.bibliographicCitation.issue8
local.bibliographicCitation.lastpage3541
local.bibliographicCitation.startpage3530
local.contributor.affiliationLiao, Yalin, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationAlvarado, Rudy, University of California
local.contributor.affiliationPhinney, Brett, University of California
local.contributor.affiliationLonnerdal, Bo, University of California
local.contributor.authoremailu5114881@anu.edu.au
local.contributor.authoruidLiao, Yalin, u5114881
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor110500 - DENTISTRY
local.identifier.ariespublicationf5625xPUB7365
local.identifier.citationvolume10
local.identifier.doi10.1021/pr200149t
local.identifier.scopusID2-s2.0-79961232783
local.identifier.uidSubmittedByf5625
local.type.statusPublished Version

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