Low levels of ATM in breast cancer patients with clinical radiosensitivity

dc.contributor.authorFang, Zhiming
dc.contributor.authorKozlov, Sergei
dc.contributor.authorMcKay, Michael J
dc.contributor.authorWoods, Rick
dc.contributor.authorBirrell, Geoff
dc.contributor.authorSprung, Carl N
dc.contributor.authorMurrell, Dédée F
dc.contributor.authorWangoo, Kiran
dc.contributor.authorTeng, Linda
dc.contributor.authorKearsley, John H
dc.contributor.authorLavin, Martin F
dc.contributor.authorGraham, Peter H
dc.contributor.authorClarke, Raymond A
dc.date.accessioned2015-12-16T05:01:31Z
dc.date.available2015-12-16T05:01:31Z
dc.date.issued2010-06-24
dc.date.updated2016-02-24T08:20:16Z
dc.description.abstractBACKGROUND AND PURPOSE Adjuvant radiotherapy for cancer can result in severe adverse side effects for normal tissues. In this respect, individuals with anomalies of the ATM (ataxia telangiectasia) protein/gene are of particular interest as they may be at risk of both breast cancer and clinical radiosensitivity. The association of specific ATM gene mutations with these pathologies has been well documented, however, there is uncertainty regarding pathological thresholds for the ATM protein. RESULTS Semi-quantitative immuno-blotting provided a reliable and reproducible method to compare levels of the ATM protein for a rare cohort of 20 cancer patients selected on the basis of their severe adverse normal tissue reactions to radiotherapy. We found that 4/12 (33%) of the breast cancer patients with severe adverse normal tissue reactions following radiotherapy had ATM protein levels < 55% compared to the mean for non-reactor controls. CONCLUSIONS ATM mutations are generally considered low risk alleles for breast cancer and clinical radiosensitivity. From results reported here we propose a tentative ATM protein threshold of ~55% for high-risk of clinical radiosensitivity for breast cancer patients.
dc.description.sponsorshipThe authors acknowledge grant support from the Royal Australian and New Zealand College of Radiologists.en_AU
dc.identifier.issn2041-9414en_AU
dc.identifier.urihttp://hdl.handle.net/1885/95068
dc.publisherBioMed Central
dc.rights© 2010 Fang et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.sourceGenome Integrity
dc.source.urihttp://www.genomeintegrity.com/content/1/1/9en_AU
dc.subjectKeywords: ATM protein; adult; aged; article; blood sampling; breast cancer; breast fibrosis; cancer patient; cancer risk; chromosome aberration; clinical article; controlled study; cystitis; desquamation; enzyme activity; female; gene mutation; genetic association;
dc.titleLow levels of ATM in breast cancer patients with clinical radiosensitivity
dc.typeJournal article
local.bibliographicCitation.issue1en_AU
local.bibliographicCitation.startpage9en_AU
local.contributor.affiliationFang, Zhiming, University of New South Wales, Australiaen_AU
local.contributor.affiliationKozlov, Sergei, Queensland Institute of Medical Research, Australiaen_AU
local.contributor.affiliationMcKay, Michael, College of Medicine, Biology and Environment, CMBE ANU Medical School, ANU Medical School, The Australian National Universityen_AU
local.contributor.affiliationWoods, Rick, Queensland Institute of Medical Research, Australiaen_AU
local.contributor.affiliationBirrell, Geoff, Queensland Institute of Medical Research, Australiaen_AU
local.contributor.affiliationSprung, Carl N., Monash University, Australiaen_AU
local.contributor.affiliationMurrell, Dedee F., University of New South Wales, Australiaen_AU
local.contributor.affiliationWangoo, Kiran, University of New South Wales, Australiaen_AU
local.contributor.affiliationTeng, Linda, Queensland Institute of Medical Research, Australiaen_AU
local.contributor.affiliationKearsley, John H, University of New South Wales, Australiaen_AU
local.contributor.affiliationLavin, Martin F., Queensland Institute of Medical Research, Australiaen_AU
local.contributor.affiliationGraham, Peter H, University of New South Wales, Australiaen_AU
local.contributor.authoruidMcKay, Michael, a276689
local.description.notesImported from ARIESen_AU
local.identifier.absfor111208en_AU
local.identifier.ariespublicationf2965xPUB1955en_AU
local.identifier.citationvolume1en_AU
local.identifier.doi10.1186/2041-9414-1-9en_AU
local.identifier.essn2041-9414en_AU
local.identifier.scopusID2-s2.0-79953798241
local.identifier.uidSubmittedByu3488905en_AU
local.type.statusPublished Versionen_AU

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