2-Phenylnaphthalenes and a polyoxygenated cyclohexene from the stem and root extracts of Uvaria cherrevensis (Annonaceae)

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dc.contributor.authorAuranwiwat, Chiramet
dc.contributor.authorWongsomboon, Puttandon
dc.contributor.authorThaima, Thanaphat
dc.contributor.authorRattanajak, Roonglawan
dc.contributor.authorKamchonwongpaisan, Sumalee
dc.contributor.authorWillis, Anthony
dc.contributor.authorLie, Wilford
dc.contributor.authorPyne, Stephen G
dc.contributor.authorRitthiwigrom, Thunwadee
dc.date.accessioned2021-04-23T01:08:12Z
dc.date.issued2017
dc.date.updated2020-11-23T10:04:06Z
dc.description.abstractThree new 2-phenylnaphthalene derivatives, cherrevenaphthalenes A–C (1–3), and a new polyoxygenated cyclohexene derivative, (−)-uvaribonol F (4) together with six known compounds, 5–10, were isolated from the stem and root extracts of Uvaria cherrevensis (Annonaceae). The structures of all isolated compounds were elucidated by spectroscopic analysis. The structures of 3 and 4 were further confirmed by single crystal X-ray diffraction methods. Compound 2 exhibited modest antiplasmodial activity against the P. falciparum stains TM4/8.2 and K1CB1 with IC50 values of 18.8 ± 3.63 and 23.4 ± 4.08 μM, respectively, and weak cytotoxicity to a Vero cell line. Furthermore, compound 4 displayed cytotoxic activity against a KB cell line with an IC50 value of 22.1 ± 0.42 μM but was non-cytotoxic to the Vero cell line. Compound 5 revealed stronger cytotoxicity towards the KB cell line, with an IC50 value of 5.05 ± 0.86 μM and was nearly equally cytotoxic to the Vero cell lineen_AU
dc.description.sponsorshipThis work was supported by a CMU Short Term Research Fellowships in Overseas. CA and PW acknowledged the Science Achievement Scholarship of Thailand (SAST), the Graduate School and The Association of Students supported by the Development and Promotion for Science and Technology talents project (ASDPST). We would like also to thank the bioassay laboratory, BIOTEC, NSTDA, Thailand for KB and Vero cells and NSTDA's Cluster Program Management for financial support to SKen_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn0367-326Xen_AU
dc.identifier.urihttp://hdl.handle.net/1885/230987
dc.language.isoen_AUen_AU
dc.publisherElsevieren_AU
dc.rights© 2017 Published by Elsevier B.Ven_AU
dc.sourceFitoterapiaen_AU
dc.subjectUvaria cherrevensisen_AU
dc.subjectAnnonaceaeen_AU
dc.subjectPhenylnaphthaleneen_AU
dc.subjectPolyoxygenated cyclohexeneen_AU
dc.subjectAntiplasmodial activityen_AU
dc.subjectCytotoxic activityen_AU
dc.title2-Phenylnaphthalenes and a polyoxygenated cyclohexene from the stem and root extracts of Uvaria cherrevensis (Annonaceae)en_AU
dc.typeJournal articleen_AU
local.bibliographicCitation.lastpage107en_AU
local.bibliographicCitation.startpage103en_AU
local.contributor.affiliationAuranwiwat, Chiramet, Chiang Mai Universityen_AU
local.contributor.affiliationWongsomboon, Puttandon, Chiang Mai Universityen_AU
local.contributor.affiliationThaima, Thanaphat, University of Wollongongen_AU
local.contributor.affiliationRattanajak, Roonglawan, National Center for Genetic Engineering and Biotechnologyen_AU
local.contributor.affiliationKamchonwongpaisan, Sumalee, National Center for Genetic Engineering and Biotechnologyen_AU
local.contributor.affiliationWillis, Anthony, College of Science, ANUen_AU
local.contributor.affiliationLie, Wilford, University of Wollongongen_AU
local.contributor.affiliationPyne, Stephen G, University of Wollongongen_AU
local.contributor.affiliationRitthiwigrom, Thunwadee, University of Wollongongen_AU
local.contributor.authoremailu8512028@anu.edu.auen_AU
local.contributor.authoruidWillis, Anthony, u8512028en_AU
local.description.embargo2099-12-31
local.description.notesImported from ARIESen_AU
local.identifier.absfor060101 - Analytical Biochemistryen_AU
local.identifier.ariespublicationa383154xPUB6168en_AU
local.identifier.citationvolume120en_AU
local.identifier.doi10.1016/j.fitote.2017.06.002en_AU
local.identifier.scopusID2-s2.0-85020308911
local.identifier.thomsonID000407404000015
local.identifier.uidSubmittedBya383154en_AU
local.publisher.urlhttps://www.elsevier.com/en-auen_AU
local.type.statusPublished Versionen_AU

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