Lifestyle factors and primary glioma and meningioma tumours in the Million Women Study cohort

dc.contributor.authorBenson, Victoria S
dc.contributor.authorPirie, Kirstin
dc.contributor.authorGreen, Jane
dc.contributor.authorCasabonne, Delphine
dc.contributor.authorBeral, Valerie
dc.contributor.authorChurch, Judith
dc.contributor.authorEnglish, Ruth
dc.contributor.authorPatnick, Julietta
dc.contributor.authorPeto, Richard
dc.contributor.authorReeves, Gillian K
dc.contributor.authorVessey, Martin
dc.contributor.authorWallis, Matthew G
dc.contributor.authorBanks, Emily
dc.date.accessioned2015-12-08T22:25:13Z
dc.date.issued2008
dc.date.updated2015-12-08T09:04:01Z
dc.description.abstractPrevious studies have reported inconsistent results on the effect of anthropometric and lifestyle factors on the risk of developing glioma or meningioma tumours. A prospective cohort of 1.3 million middle-aged women was used to examine these relationships. During 7.7 million women-years of follow-up, a total of 1563 women were diagnosed with a primary incident central nervous system tumour: 646 tumours were classified as glioma and 390 as meningioma. Our results show that height is related to the incidence of all central nervous system tumours with a risk of about 20% per 10 cm increase in height (relative risk = 1.19, 95% CI = 1.10-1.30 per 10 cm increase in height, P < 0.001): the risks did not differ significantly between specified glioma and meningioma. Body mass index (BMI) was also related to central nervous system tumour incidence, with a risk of about 20% per 10 kg m-2 increase in BMI (relative risk = 1.17, 95% CI = 1.03-1.34 per 10 kg m-2 increase in BMI, P = 0.02). Smoking status, alcohol intake, socioeconomic level, parity, age at first birth, and oral contraceptive use were not associated with the risk of glioma or meningioma tumours. In conclusion, for women in the United Kingdom, the incidence of glioma or meningioma tumours increases with increasing height and increasing BMI.
dc.identifier.issn0007-0920
dc.identifier.urihttp://hdl.handle.net/1885/33351
dc.publisherNature Publishing Group
dc.sourceBritish Journal of Cancer
dc.subjectKeywords: oral contraceptive agent; adult; aged; alcohol consumption; anthropometry; article; body height; body mass; central nervous system tumor; cohort analysis; confidence interval; correlation analysis; female; follow up; glioma; human; incidence; lifestyle; m Body mass index; Glioma; Height; Meningioma; Women
dc.titleLifestyle factors and primary glioma and meningioma tumours in the Million Women Study cohort
dc.typeJournal article
local.bibliographicCitation.lastpage90
local.bibliographicCitation.startpage185
local.contributor.affiliationBenson, Victoria S, University of Oxford
local.contributor.affiliationPirie, Kirstin, University of Oxford
local.contributor.affiliationGreen, Jane, University of Oxford
local.contributor.affiliationCasabonne, Delphine, University of Oxford
local.contributor.affiliationBeral, Valerie, University of Oxford
local.contributor.affiliationChurch, Judith, University of Oxford
local.contributor.affiliationEnglish, Ruth, University of Oxford
local.contributor.affiliationPatnick, Julietta, National Health Service Cancer Screening Programmes
local.contributor.affiliationPeto, Richard, Oxford University
local.contributor.affiliationReeves, Gillian K, University of Oxford
local.contributor.affiliationVessey, Martin, Oxford University
local.contributor.affiliationWallis, Matthew G, Coventry and Warwick Hospital
local.contributor.affiliationBanks, Emily, College of Medicine, Biology and Environment, ANU
local.contributor.authoremailu4106314@anu.edu.au
local.contributor.authoruidBanks, Emily, u4106314
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor111202 - Cancer Diagnosis
local.identifier.ariespublicationu4468094xPUB101
local.identifier.citationvolume99
local.identifier.doi10.1038/sj.bjc.6604445
local.identifier.scopusID2-s2.0-46349085545
local.identifier.thomsonID000257325000031
local.identifier.uidSubmittedByu4468094
local.type.statusPublished Version

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