Oxidation of threonine residues with IBX reagents

Date

2009

Authors

Manohari Abeysinghe, P
Han, Yu
Harding, Margaret

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier

Abstract

The treatment of protected Thr peptides with excess polymer-bound IBX effects sequential oxidation of the Thr secondary alcohol to the ketone, followed by hydroxylation of the alpha carbon of the Thr residues with loss of stereochemistry at this position.

Description

Keywords

Keywords: amino acid; benzoic acid; iodoxybenzoic acid; threonine; unclassified drug; article; carbon nuclear magnetic resonance; chemical reaction; chemical structure; hydroxylation; oxidation; proton nuclear magnetic resonance; synthesis Antifreeze proteins; o-Iodoxybenzoic acid (IBX); Threonine oxidation

Citation

Source

Tetrahedron Letters

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1016/j.tetlet.2009.03.107

Restricted until

2037-12-31