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Oxidation of threonine residues with IBX reagents

Date

Authors

Manohari Abeysinghe, P

Han, Yu

Harding, Margaret

Publisher

Elsevier

Abstract

The treatment of protected Thr peptides with excess polymer-bound IBX effects sequential oxidation of the Thr secondary alcohol to the ketone, followed by hydroxylation of the alpha carbon of the Thr residues with loss of stereochemistry at this position.

Keywords

Keywords: amino acid; benzoic acid; iodoxybenzoic acid; threonine; unclassified drug; article; carbon nuclear magnetic resonance; chemical reaction; chemical structure; hydroxylation; oxidation; proton nuclear magnetic resonance; synthesis Antifreeze proteins; o-Iodoxybenzoic acid (IBX); Threonine oxidation

URI

http://hdl.handle.net/1885/73592

Collections

ANU Research Publications

Source

Tetrahedron Letters

Type

Journal article

DOI

10.1016/j.tetlet.2009.03.107

Restricted until

2037-12-31

Downloads

File

Description

01_Manohari Abeysinghe_Oxidation_of_threonine_2009.pdf (392.33 KB)

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