Cultural advice

The Australian National University acknowledges, celebrates and pays our respects to the Ngunnawal and Ngambri people of the Canberra region and to all First Nations Australians on whose traditional lands we meet and work, and whose cultures are among the oldest continuing cultures in human history.

Aboriginal and Torres Strait Islander peoples are advised that ANU Library collections may include images, names, voices, and other representations of deceased persons.

Material in the collection may contain terms, language or views that reflect the period in which the item was created and may be considered inappropriate today.

Covalent trapping of methyllycaconitine at the α4-α4 interface of the α4β2 nicotinic acetylcholine receptor: antagonist binding site and mode of receptor inhibition revealed

Simple item page
dc.contributor.authorAbsalom, Nathan
dc.contributor.authorQuek, Gracia X J
dc.contributor.authorLewis, Trevor M.
dc.contributor.authorQudah, Taima
dc.contributor.authorvon Arenstorff, Ida
dc.contributor.authorAmbrus, Joseph
dc.contributor.authorHarpsoe, Kaspar
dc.contributor.authorKarim, Nasiara
dc.contributor.authorBalle, Thomas
dc.contributor.authorMcLeod, Malcolm
dc.contributor.authorChebib, Mary
dc.date.accessioned2015-12-10T23:04:23Z
dc.date.issued2013
dc.date.updated2016-02-24T10:25:50Z
dc.description.abstractBackground: Methyllycaconitine is an antagonist at subtypes of the nicotinic acetylcholine receptor. Results: A reactive methyllycaconitine probe was covalently trapped by a cysteine introduced on the complementary face of the α4 subunit and only in the
dc.identifier.issn0021-9258
dc.identifier.urihttp://hdl.handle.net/1885/62348
dc.publisherAmerican Society for Biochemistry and Molecular Biology Inc
dc.rightsAuthor/s retain copyrighten_AU
dc.sourceJournal of Biological Chemistry
dc.subjectKeywords: Nicotinic acetylcholine receptors; Biochemistry; Biology; Amino acids; acetylcholine; methyllycaconitine; nicotinic receptor alpha4beta2; animal cell; article; controlled study; covalent bond; drug binding site; drug protein binding; drug structure; drug
dc.titleCovalent trapping of methyllycaconitine at the α4-α4 interface of the α4β2 nicotinic acetylcholine receptor: antagonist binding site and mode of receptor inhibition revealed
dc.typeJournal article
dcterms.accessRightsOpen Accessen_AU
local.bibliographicCitation.issue37
local.bibliographicCitation.lastpage26532
local.bibliographicCitation.startpage26521
local.contributor.affiliationAbsalom, Nathan, University of Sydney
local.contributor.affiliationQuek, Gracia X J, University of Sydney
local.contributor.affiliationLewis, Trevor M., University of New South Wales
local.contributor.affiliationQudah, Taima, University of Sydney
local.contributor.affiliationvon Arenstorff, Ida, University of Sydney
local.contributor.affiliationAmbrus, Joseph, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationHarpsoe, Kaspar, University of Copenhagen
local.contributor.affiliationKarim, Nasiara, University of Sydney
local.contributor.affiliationBalle, Thomas, University of Sydney
local.contributor.affiliationMcLeod, Malcolm, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationChebib, Mary, University of Sydney
local.contributor.authoruidAmbrus, Joseph, u4562284
local.contributor.authoruidMcLeod, Malcolm, u4045340
local.description.notesImported from ARIES
local.identifier.absfor030503 - Organic Chemical Synthesis
local.identifier.absseo970106 - Expanding Knowledge in the Biological Sciences
local.identifier.ariespublicationu4005981xPUB690
local.identifier.citationvolume288
local.identifier.doi10.1074/jbc.M113.475053
local.identifier.scopusID2-s2.0-84884193367
local.identifier.thomsonID000330594500019
local.type.statusPublished Version

Downloads

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
01_Absalom_Covalent_trapping_of_2013.pdf
Size:
2.69 MB
Format:
Adobe Portable Document Format
Download

Collections

ANU Research Publications

DSpace software copyright © 2002-2026 LYRASIS