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Unique transcriptional profile of liver-resident memory CD8+ T cells induced by immunization with malaria sporozoites

Date

Authors

Cockburn, Ian

Tse, Sze-Wah

Zhang, H

Scott, AL

Zavala, Fidel

Publisher

Nature Publishing Group

Abstract

Sterile immunity against live Plasmodium infection can be achieved by immunization with radiation-attenuated sporozoites. This protection is known to be mediated in part by antigen-specific memory CD8+ T cells, presumably those residing in the liver. We c

Keywords

Keywords: malaria vaccine; sporozoite vaccine; animal cell; animal experiment; animal model; article; CD8+ T lymphocyte; controlled study; female; gene expression profiling; genetic transcription; immunization; liver; memory T lymphocyte; microarray analysis; mouse CD8+ T cells; Liver-stage; Malaria; Memory; Plasmodium; Sporozoites

URI

http://hdl.handle.net/1885/81508

Collections

ANU Research Publications

Source

Genes and Immunity

Type

Journal article

DOI

10.1038/gene.2013.20

Restricted until

2037-12-31

Downloads

File

Description

01_Cockburn_Unique_transcriptional_profile_2013.pdf (2.27 MB)

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