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Homologous mutations in two diverse sulphate transporters have similar effects

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dc.contributor.authorKhurana, O
dc.contributor.authorCoupland, Lucy
dc.contributor.authorShelden, Megan
dc.contributor.authorHowitt, Susan
dc.date.accessioned2015-12-13T23:19:48Z
dc.date.issued2000
dc.date.updated2015-12-12T09:00:59Z
dc.description.abstractMutations in the human sulphate transporter gene, DTDST, have been implicated in several diseases. Analysis of affected patients has linked disease symptoms to faulty sulphate transporter activity. We have reproduced two of these mutations in SHST1, a homologous member of the family isolated from the tropical legume, Stylosanthes hamata. Both mutations significantly reduce sulphate transport activity of SHST1. These results indicate that conserved residues between distinct members of the family may share essential roles in structure or function. The results also suggest that putative helix 9 may be important for stability and/or trafficking of SHST1 to the plasma membrane.
dc.identifier.issn0014-5793
dc.identifier.urihttp://hdl.handle.net/1885/90434
dc.publisherElsevier
dc.sourceFEBS Letters
dc.subjectKeywords: carrier protein; mutant protein; sulfate; achondroplasia; article; chondrodysplasia; gene construct; gene expression; gene mutation; genetic analysis; human; ion transport; nonhuman; plant; priority journal; protein analysis; protein family; sequence homo Diastrophic dysplasia; Site-directed mutagenesis; Sulfate transporter; Transmembrane helix
dc.titleHomologous mutations in two diverse sulphate transporters have similar effects
dc.typeJournal article
local.bibliographicCitation.lastpage122
local.bibliographicCitation.startpage118
local.contributor.affiliationKhurana, O, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationCoupland, Lucy, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationShelden, Megan, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationHowitt, Susan, College of Medicine, Biology and Environment, ANU
local.contributor.authoruidKhurana, O, u3605413
local.contributor.authoruidCoupland, Lucy, u3562509
local.contributor.authoruidShelden, Megan, u9806997
local.contributor.authoruidHowitt, Susan, u8303695
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor060110 - Receptors and Membrane Biology
local.identifier.ariespublicationMigratedxPub20789
local.identifier.citationvolume477
local.identifier.doi10.1016/S0014-5793(00)01783-X
local.identifier.scopusID2-s2.0-0034648013
local.type.statusPublished Version

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