Cultural advice

The Australian National University acknowledges, celebrates and pays our respects to the Ngunnawal and Ngambri people of the Canberra region and to all First Nations Australians on whose traditional lands we meet and work, and whose cultures are among the oldest continuing cultures in human history.

Aboriginal and Torres Strait Islander peoples are advised that ANU Library collections may include images, names, voices, and other representations of deceased persons.

Material in the collection may contain terms, language or views that reflect the period in which the item was created and may be considered inappropriate today.

Model studies toward the synthesis of the bioactive diterpenoid, harringtonolide

Thumbnail Image

Date

2007

Authors

O'Sullivan, Timothy
Zhang, Hongbin
Mander, Lewis

Journal Title

Journal ISSN

Volume Title

Publisher

Royal Society of Chemistry

Abstract

In model studies towards the synthesis of harringtonolide, the construction of the tropone moiety via arene cyclopropanation was investigated. The installation of the lactone ring was accomplished by way of a Diels-Alder cycloaddition of various indenones and α-pyones. The incorporation of the key bridge methyl group and subsequent control of its stereochemistry is also outlined.

Description

Keywords

Keywords: Cyclopropanation; Diels-Alder cycloaddition; Diterpenoid; Harringtonolide; Lactone ring; Aromatic compounds; Bioactivity; Biosynthesis; Functional groups; Ketones; Stereochemistry; Biomolecules; diterpene; hainanolide; harringtonine derivative; unclassifi

Citation

URI

http://hdl.handle.net/1885/29398

Collections

ANU Research Publications

Source

Organic and Biomolecular Chemistry

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1039/b707467k

Restricted until

2037-12-31

Downloads

File
Description
01_O'Sullivan_Model_studies_toward_the_2007.pdf (268.17 KB)

DSpace software copyright © 2002-2026 LYRASIS