Increased functional connectivity of thalamic subdivisions in patients with Parkinson's disease
dc.contributor.author | Owens-Walton, Conor | |
dc.contributor.author | Jakabek, David | |
dc.contributor.author | Power, Brian | |
dc.contributor.author | Walterfang, Mark | |
dc.contributor.author | Velakoulis, Dennis | |
dc.contributor.author | van Westen, Danielle | |
dc.contributor.author | Looi, Jeffrey | |
dc.contributor.author | Shaw, Marnie | |
dc.contributor.author | Hansson, Oskar | |
dc.date.accessioned | 2020-12-23T01:01:28Z | |
dc.date.available | 2020-12-23T01:01:28Z | |
dc.date.issued | 2019-09-04 | |
dc.date.updated | 2020-09-20T08:22:49Z | |
dc.description.abstract | Parkinson's disease (PD) affects 2-3% of the population over the age of 65 with loss of dopaminergic neurons in the substantia nigra impacting the functioning of basal ganglia-thalamocortical circuits. The precise role played by the thalamus is unknown, despite its critical role in the functioning of the cerebral cortex, and the abnormal neuronal activity of the structure in PD. Our objective was to more clearly elucidate how functional connectivity and morphology of the thalamus are impacted in PD (n = 32) compared to Controls (n = 20). To investigate functional connectivity of the thalamus we subdivided the structure into two important regions-of-interest, the first with putative connections to the motor cortices and the second with putative connections to prefrontal cortices. We then investigated potential differences in the size and shape of the thalamus in PD, and how morphology and functional connectivity relate to clinical variables. Our data demonstrate that PD is associated with increases in functional connectivity between motor subdivisions of the thalamus and the supplementary motor area, and between prefrontal thalamic subdivisions and nuclei of the basal ganglia, anterior and dorsolateral prefrontal cortices, as well as the anterior and paracingulate gyri. These results suggest that PD is associated with increased functional connectivity of subdivisions of the thalamus which may be indicative alterations to basal ganglia-thalamocortical circuitry. | en_AU |
dc.description.sponsorship | CO-W would like to acknowledge the Australian National University for their funding support via the University Research Scholarship. Work in DvW and OH’s laboratory was supported by the European Research Council, the Swedish Research Council, the Strategic Research Area MultiPark (Multidisciplinary Research in Parkinson’s disease) at Lund University, the Swedish Brain Foundation, the Parkinson Foundation of Sweden, the Skåne University Hospital Foundation and the Swedish federal government under the ALF agreement. | en_AU |
dc.format.mimetype | application/pdf | en_AU |
dc.identifier.citation | Owens-Walton C, Jakabek D, Power BD, Walterfang M, Velakoulis D, van Westen D, et al. (2019) Increased functional connectivity of thalamic subdivisions in patients with Parkinson’s disease. PLoS ONE 14(9): e0222002. https://doi. org/10.1371/journal.pone.0222002 | en_AU |
dc.identifier.issn | 1932-6203 | en_AU |
dc.identifier.uri | http://hdl.handle.net/1885/219039 | |
dc.language.iso | en_AU | en_AU |
dc.provenance | This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en_AU |
dc.publisher | Public Library of Science | en_AU |
dc.rights | © 2019 Owens-Walton et al | en_AU |
dc.rights.license | Creative Commons Attribution License | en_AU |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_AU |
dc.source | PLOS ONE (Public Library of Science) | en_AU |
dc.title | Increased functional connectivity of thalamic subdivisions in patients with Parkinson's disease | en_AU |
dc.type | Journal article | en_AU |
dcterms.accessRights | Open Access | en_AU |
dcterms.dateAccepted | 2019-08-20 | |
local.bibliographicCitation.issue | 9 | en_AU |
local.bibliographicCitation.lastpage | 17 | en_AU |
local.bibliographicCitation.startpage | 1 | en_AU |
local.contributor.affiliation | Owens-Walton, Conor, College of Science, ANU | en_AU |
local.contributor.affiliation | Jakabek, David, University of Wollongong | en_AU |
local.contributor.affiliation | Power, Brian, The University of Notre Dame | en_AU |
local.contributor.affiliation | Walterfang, Mark, Royal Melbourne Hospital | en_AU |
local.contributor.affiliation | Velakoulis, Dennis, Royal Melbourne Hospital | en_AU |
local.contributor.affiliation | van Westen, Danielle, Lund University | en_AU |
local.contributor.affiliation | Looi, Jeffrey, College of Health and Medicine, ANU | en_AU |
local.contributor.affiliation | Shaw, Marnie, College of Engineering and Computer Science, ANU | en_AU |
local.contributor.affiliation | Hansson, Oskar, Lund University | en_AU |
local.contributor.authoremail | u4593152@anu.edu.au | en_AU |
local.contributor.authoruid | Owens-Walton, Conor, u4307082 | en_AU |
local.contributor.authoruid | Looi, Jeffrey, u4593152 | en_AU |
local.contributor.authoruid | Shaw, Marnie, u3627775 | en_AU |
local.description.notes | Imported from ARIES | en_AU |
local.identifier.absfor | 111714 - Mental Health | en_AU |
local.identifier.absseo | 920410 - Mental Health | en_AU |
local.identifier.ariespublication | u5786633xPUB1703 | en_AU |
local.identifier.citationvolume | 14 | en_AU |
local.identifier.doi | 10.1371/journal.pone.0222002 | en_AU |
local.identifier.thomsonID | WOS:000486313000055 | |
local.identifier.uidSubmittedBy | u5786633 | en_AU |
local.publisher.url | https://journals.plos.org/ | en_AU |
local.type.status | Published Version | en_AU |
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