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Apathy associated with neurocognitive disorders: recent progress and future directions

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dc.contributor.authorLanctôt, Krista
dc.contributor.authorAgüera-Ortiz, Luis
dc.contributor.authorBrodaty, Henry
dc.contributor.authorFrancis, Paul
dc.contributor.authorGeda, Yonas
dc.contributor.authorIsmail, Zahinoor
dc.contributor.authorMarshall, Gad
dc.contributor.authorMortby, Moyra
dc.contributor.authorOnyike, Chiadi U
dc.contributor.authorPadala, Prasad R
dc.contributor.authorPolitis, Antonios M
dc.date.accessioned2021-05-10T01:26:58Z
dc.date.issued2017
dc.date.updated2020-11-23T10:11:55Z
dc.description.abstractIntroduction: Apathy is common in neurocognitive disorders (NCDs) such as Alzheimer’s disease and mild cognitive impairment. Although the definition of apathy is inconsistent in the literature, apathy is primarily defined as a loss of motivation and decreased interest in daily activities. Methods: The Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment (ISTAART) Neuropsychiatric Syndromes Professional Interest Area (NPS-PIA) Apathy workgroup reviewed the latest research regarding apathy in NCDs. Results: Progress has recently been made in three areas relevant to apathy: (1) phenomenology, including the use of diagnostic criteria and novel instruments for measurement, (2) neurobiology, including neuroimaging, neuropathological and biomarker correlates, and (3) interventions, including pharmacologic, nonpharmacologic, and noninvasive neuromodulatory approaches. Discussion: Recent progress confirms that apathy has a significant impact on those with major NCD and those with mild NCDs. As such, it is an important target for research and intervention.en_AU
dc.description.sponsorshipK.L.L. and P.B.R. are funded by the National Institute of Aging for “Apathy in Alzheimer’s Disease Methylphenidate Trial II (ADMET II)” (award number R01AG046543). Z.I. is funded by the Alzheimer Society Calgary, via the Hotchkiss Brain Institute. M.E.M. is funded by the Australian National Health and Medical Research Council (NHMRC)— Australian Research Council (ARC) Dementia Research Development Fellowship (grant #1102028) and by an Alzheimer’s Australia Dementia Research Foundation (AADRF) grant (#13F00029). C.U.O. is supported by NIH/NIA grants P50AG05146 and U19AG033655, NIH/ NINDS grant 1U54NS092089-01, TRx 237-007 from Tau Therapeutics, the Jane Tanger Black Fund for YoungOnset Dementia Research, and the Robert and Nancy Hall family. This work was supported in part by the Department of Veterans Affairs (Merit Review Award, Dr. Sultzer). P.R.P. is funded by South Central VA Health Care Network Research Grant Program from the National Institute of Aging, Department of Veterans Affairs.en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn1552-5260en_AU
dc.identifier.urihttp://hdl.handle.net/1885/232563
dc.language.isoen_AUen_AU
dc.publisherElsevieren_AU
dc.relationhttp://purl.org/au-research/grants/nhmrc/1102028en_AU
dc.rights© 2016 the Alzheimer’s Associationen_AU
dc.sourceAlzheimer's & Dementiaen_AU
dc.subjectApathyen_AU
dc.subjectAlzheimer’s disease (AD)en_AU
dc.subjectMild behavioral impairment (MBI)en_AU
dc.subjectneuropsychiatric symptoms (NPS)en_AU
dc.subjectNeurocognitive disorders (NCD)en_AU
dc.titleApathy associated with neurocognitive disorders: recent progress and future directionsen_AU
dc.typeJournal articleen_AU
local.bibliographicCitation.issue1en_AU
local.bibliographicCitation.lastpage100en_AU
local.bibliographicCitation.startpage84en_AU
local.contributor.affiliationLanctôt, Krista, University of Torontoen_AU
local.contributor.affiliationAgüera-Ortiz, Luis, Department of Psychiatry & Research Institute Hospitalen_AU
local.contributor.affiliationBrodaty, Henry, University of New South Walesen_AU
local.contributor.affiliationFrancis, Paul, King's College Londonen_AU
local.contributor.affiliationGeda, Yonas, Mayo Clinicen_AU
local.contributor.affiliationIsmail, Zahinoor, University of Calgaryen_AU
local.contributor.affiliationMarshall, Gad, Harvard Medical Schoolen_AU
local.contributor.affiliationMortby, Moyra, College of Health and Medicine, ANUen_AU
local.contributor.affiliationOnyike, Chiadi U, Johns Hopkins University School of Medicineen_AU
local.contributor.affiliationPadala, Prasad R, Geriatric Research Education and Clinical Centeren_AU
local.contributor.affiliationPolitis, Antonios M, National and Kapodistrian Universityen_AU
local.contributor.authoruidMortby, Moyra, u5080546en_AU
local.description.embargo2099-12-31
local.description.notesImported from ARIESen_AU
local.identifier.absfor170102 - Developmental Psychology and Ageingen_AU
local.identifier.absfor170205 - Neurocognitive Patterns and Neural Networksen_AU
local.identifier.ariespublicationu5080546xPUB14en_AU
local.identifier.citationvolume13en_AU
local.identifier.doi10.1016/j.jalz.2016.05.008en_AU
local.identifier.scopusID2-s2.0-84996773938
local.identifier.thomsonID000391912300009
local.publisher.urlhttps://www.elsevier.com/en-auen_AU
local.type.statusPublished Versionen_AU

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