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A Model of the Glycine Receptor Deduced from Brownian Dynamics Studies

Date

Authors

O'Mara, Megan

Barry, P H

Chung, Shin-Ho

Publisher

National Academy of Sciences (USA)

Abstract

We have developed a three-dimensional model of the α1 homomeric glycine receptor by using Brownian dynamics simulations to account for its observed physiological properties. The model channel contains a large external vestibule and a shallow internal ves

Keywords

Keywords: alanine; amino acid; anion; cation; glycine receptor; ion channel; sodium ion; recombinant protein; amino acid sequence; article; extracellular space; filter; hormone receptor interaction; ion permeability; membrane permeability; molecular dynamics; molec Conductance; Ligand-gated ion channels; Permeation

URI

http://hdl.handle.net/1885/87164

Collections

ANU Research Publications

Source

PNAS - Proceedings of the National Academy of Sciences of the United States of America

Type

Journal article

DOI

10.1073/pnas.0630652100

Restricted until

2037-12-31

Downloads

File

Description

01_O'Mara_A_Model_of_the_Glycine_2003.pdf (288.22 KB)