Beta cells cannot directly prime diabetogenic CD8 T cells in nonobese diabetic mice
Date
2007
Authors
de Jersey, James
Snelgrove, Sarah L
Palmer, Stephanie
Teteris, Simon
Mullbacher, Arno
Miller, Jacques
Slattery, Robyn
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Publisher
National Academy of Sciences (USA)
Abstract
Type 1 diabetes (T1D) is caused by the destruction of insulin-producing islet β cells. CD8 T cells are prevalent in the islets of T1D patients and are the major effectors of β cell destruction in nonobese diabetic (NOD) mice. In addition to their critic
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Keywords
Keywords: beta 2 microglobulin; animal cell; animal experiment; animal model; antigen expression; antigen presenting cell; article; autoimmunity; CD8+ T lymphocyte; controlled study; female; flow cytometry; gene inactivation; gene targeting; insulin dependent diabe Antigen-presenting cells; Autoimmunity; Insulitis; Type 1 diabetes
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PNAS - Proceedings of the National Academy of Sciences of the United States of America
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Journal article
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Restricted until
2037-12-31
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