Avoiding the oligomeric state: αB-crystallin inhibits fragmentation and induces dissociation of apolipoprotein C-II amyloid fibrils

Binger, Katrina J.; Ecroyd, Heath; Yang, Shuo; Carver, John; Howlett, Geoffrey; Griffin, Michael D.W.

Avoiding the oligomeric state: αB-crystallin inhibits fragmentation and induces dissociation of apolipoprotein C-II amyloid fibrils

Date

2013

Authors

Binger, Katrina J.

Ecroyd, Heath

Yang, Shuo

Carver, John

Howlett, Geoffrey

Griffin, Michael D.W.

Publisher

Federation of American Societies for Experimental Biology

Abstract

The in vivo aggregation of proteins into amyloid fibrils suggests that cellular mechanisms that normally prevent or reverse this aggregation have failed. The small heat-shock molecular chaperone protein αB-crystallin (αB-c) inhibits amyloid formation an