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NTproBNP concentrations in healthy children

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dc.contributor.authorKoerbin, Gus
dc.contributor.authorAbhayaratna, Walter
dc.contributor.authorPotter, Julia
dc.contributor.authorApostoloska, S.
dc.contributor.authorTelford, Richard
dc.contributor.authorHickman, Peter
dc.date.accessioned2015-12-08T22:40:18Z
dc.date.issued2012
dc.date.updated2016-02-24T11:31:16Z
dc.description.abstractIntroduction: There have been limited studies generating BNP and NT-proBNP reference intervals for paediatric populations. We prospectively assessed NT-proBNP levels in a cohort of 854 healthy school children from the Lifestyle of Our Kids (LOOK) prospective longitudinal study. Materials and methods: NT-proBNP analysis was performed on 172 girls and 212 boys with average age 8.1 years, 183 girls and 181 boys, average age 10.1 years and 183 girls and 180 boys with average age 11.9 years. Data were stratified according to age and gender with the median, range of results and 2.5th and 97.5th percentiles calculated. Results: There were no significant differences between males and females at any of the 3 study ages. Significant differences were seen between the 8 and 12 year-olds, 10 and 12 year-olds and the 8 and 12 year-old boys. Discussion: Our study demonstrated that NT-proBNP concentrations in healthy children progressively decline between ages 8 and 12 years. Our selection of unambiguously healthy children produced similar median but lower 97.5th percentile NT-proBNP concentrations to previously published studies.
dc.identifier.issn0009-9120
dc.identifier.urihttp://hdl.handle.net/1885/36444
dc.publisherElsevier
dc.sourceClinical Biochemistry
dc.subjectKeywords: amino terminal pro brain natriuretic peptide; article; child; clinical assessment; cohort analysis; data analysis; female; human; human experiment; longitudinal study; male; medical record; normal human; priority journal; prospective study; protein blood Children; NT-proBNP
dc.titleNTproBNP concentrations in healthy children
dc.typeJournal article
local.bibliographicCitation.lastpage3
local.bibliographicCitation.startpage1
local.contributor.affiliationKoerbin, Gus, ACT Health
local.contributor.affiliationAbhayaratna, Walter, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationPotter, Julia, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationApostoloska, S., ACT Pathology
local.contributor.affiliationTelford, Richard, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationHickman, Peter, College of Medicine, Biology and Environment, ANU
local.contributor.authoruidAbhayaratna, Walter, u3379649
local.contributor.authoruidPotter, Julia, a182537
local.contributor.authoruidTelford, Richard, a223181
local.contributor.authoruidHickman, Peter, a168957
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor110316 - Pathology
local.identifier.ariespublicationu4971216xPUB136
local.identifier.citationvolumeOnline
local.identifier.doi10.1016/j.clinbiochem.2012.05.008
local.identifier.scopusID2-s2.0-84866284217
local.identifier.thomsonID000309631000007
local.type.statusPublished Version

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