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Vancomycin: ligand recognition, dimerization and super-complex formation

Date

Authors

Jia, ZhiGuang

O'Mara, Megan

Zuegg, Johannes

Cooper, Matthew A.

Mark, Alan E.

Publisher

Blackwell Publishing Ltd

Abstract

The antibiotic vancomycin targets lipid II, blocking cell wall synthesis in Gram-positive bacteria. Despite extensive study, questions remain regarding how it recognizes its primary ligand and what is the most biologically relevant form of vancomycin. In

Keywords

Keywords: dimer; dimethyl sulfoxide; lipid; vancomycin; water; antibiotic resistance; article; complex formation; conformational transition; dimerization; drug structure; ligand binding; molecular dynamics; nuclear magnetic resonance spectroscopy; nuclear Overhause antibiotic resistance; computer simulation; glycopeptide antibiotics; lipid II; molecular dynamics

URI

http://hdl.handle.net/1885/31980

Collections

ANU Research Publications

Source

The FEBS Journal

Type

Journal article

DOI

10.1111/febs.12121

Restricted until

2037-12-31

Downloads

File

Description

01_Jia_Vancomycin:_ligand_2014.pdf (676.6 KB)