The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells

Date

2013

Authors

Gatto, Dominique
Wood, Katherine
Caminschi, Irina
Murphy-Durland, Danielle
Schofield, Peter
Christ, Daniel
Karupiah, Gunasegaran
Brink, Robert

Journal Title

Journal ISSN

Volume Title

Publisher

Nature Publishing Group

Abstract

Spleen-resident dendritic cell (DC) populations occupy sentinel positions for the capture and presentation of blood-borne antigens. Here we found a difference in expression of the chemotactic receptor EBI2 (GPR183) on splenic DC subsets and that EBI2 regu

Description

Keywords

Keywords: CD4 antigen; G protein coupled receptor; ligand; protein EBI2; unclassified drug; animal cell; animal tissue; article; CD4+ T lymphocyte; cell function; cell migration; cell subpopulation; cell survival; chemotaxis; controlled study; dendritic cell; homeo

Citation

Source

Nature Immunology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1038/ni.2555

Restricted until

2037-12-31