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Friend or foe: endoplasmic reticulum protein 29 (ERp29) in epithelial cancer

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dc.contributor.authorChen, Shaohua
dc.contributor.authorZhang, Daohai
dc.date.accessioned2015-03-31T02:40:51Z
dc.date.available2015-03-31T02:40:51Z
dc.date.issued2015
dc.description.abstractThe endoplasmic reticulum (ER) protein 29 (ERp29) is a molecular chaperone that plays a critical role in protein secretion from the ER in eukaryotic cells. Recent studies have also shown that ERp29 plays a role in cancer. It has been demonstrated that ERp29 is inversely associated with primary tumor development and functions as a tumor suppressor by inducing cell growth arrest in breast cancer. However, ERp29 has also been reported to promote epithelial cell morphogenesis, cell survival against genotoxic stress and distant metastasis. In this review, we summarize the current understanding on the biological and pathological functions of ERp29 in cancer and discuss the pivotal aspects of ERp29 as "friend or foe" in epithelial cancer.en_AU
dc.identifier.issn2211-5463en_AU
dc.identifier.urihttp://hdl.handle.net/1885/13121
dc.publisherElsevieren_AU
dc.rightshttp://www.sherpa.ac.uk/romeo/issn/2211-5463/..."Publisher's version/PDF may be used" SHERPA/RoMEO site (as at 31/03/15). © 2015 The Authors. Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)en_AU
dc.sourceFEBS Open Bioen_AU
dc.subjectchemo-/radio-resistanceen_AU
dc.subjectdna stabilityen_AU
dc.subjecterp29en_AU
dc.subjectepithelial cell plasticityen_AU
dc.subjectmesenchymal–epithelial transitionen_AU
dc.subjectmetastasisen_AU
dc.titleFriend or foe: endoplasmic reticulum protein 29 (ERp29) in epithelial canceren_AU
dc.typeJournal articleen_AU
dcterms.dateAccepted2015-01-21
local.bibliographicCitation.lastpage98en_AU
local.bibliographicCitation.startpage91en_AU
local.contributor.affiliationZhang, D., Cancer Research Group, The Canberra Hospital, ANU Medical School, Australia National Universityen_AU
local.contributor.authoruidu5615543en_AU
local.identifier.citationvolume5en_AU
local.identifier.doi10.1016/j.fob.2015.01.004en_AU
local.identifier.essn2211-5463en_AU
local.publisher.urlhttp://www.elsevier.com/en_AU
local.type.statusPublished Versionen_AU

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