Higher Blood Pressure is Associated with Greater White Matter Lesions and Brain Atrophy: A Systematic Review with Meta-Analysis

dc.contributor.authorAlateeq, Khawlah
dc.contributor.authorWalsh, Erin
dc.contributor.authorCherbuin, Nicolas
dc.date.accessioned2024-02-26T01:32:05Z
dc.date.available2024-02-26T01:32:05Z
dc.date.issued2021
dc.date.updated2022-10-09T07:17:10Z
dc.description.abstractBackground: To summarise and quantify the evidence on the association between Blood pressure (BP), white matter lesions (WMLs), and brain volumes. Method: Electronic databases Pub-Med, Scopus, and Clarivate were searched in February 2020 using an established methodology and pre-determined search terms. Studies were eligible for inclusion if they reported on the association between BP and WMLs or brain volume in cognitively healthy individuals, while adjusting for age and intra-cranial volume. Results: Searches yielded 7509 articles, of which 52 (26 longitudinal and 33 cross-sectional), were eligible and had a combined sample size of 343,794 individuals. Analyses found that 93.7% of studies reported that higher BP was associated with poorer cerebral health (higher WMLs and lower brain volumes). Meta-analysis of compatible results indicated a dose-de-pendent relationship with every one standard deviation increase in systolic BP (SBP) above 120 mmHg being associated with a 11.2% (95% CI 2.3, 19.9, p = 0.0128) increase in WMLs and-0.13% (95% CI–0.25, −0.023, p = 0.0183) smaller hippocampal volume. Conclusion: The association between BP and brain volumes appears across the full range of BP measurements and is not limited to hypertensive individuals. Higher BP in community-residing individuals is associated with poorer cerebral health.en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn2077-0383en_AU
dc.identifier.urihttp://hdl.handle.net/1885/313894
dc.language.isoen_AUen_AU
dc.provenanceThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).en_AU
dc.publisherMDPIen_AU
dc.rights© 2021 by the authors. Licensee MDPI, Basel, Switzerland.en_AU
dc.rights.licenseCreative Commons Attribution Licenseen_AU
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_AU
dc.sourceJournal of Clinical Medicineen_AU
dc.subjectblood pressureen_AU
dc.subjectwhite matter lesionsen_AU
dc.subjecttotal brainen_AU
dc.subjecthippocampusen_AU
dc.subjectmagnetic resonance imagingen_AU
dc.titleHigher Blood Pressure is Associated with Greater White Matter Lesions and Brain Atrophy: A Systematic Review with Meta-Analysisen_AU
dc.typeJournal articleen_AU
dcterms.accessRightsOpen Accessen_AU
local.bibliographicCitation.issue4en_AU
local.bibliographicCitation.lastpage19en_AU
local.bibliographicCitation.startpage1en_AU
local.contributor.affiliationAlateeq, Khawlah, College of Health and Medicine, ANUen_AU
local.contributor.affiliationWalsh, Erin, College of Health and Medicine, ANUen_AU
local.contributor.affiliationCherbuin, Nicolas, College of Health and Medicine, ANUen_AU
local.contributor.authoremailu3184049@anu.edu.auen_AU
local.contributor.authoruidAlateeq, Khawlah, u6816387en_AU
local.contributor.authoruidWalsh, Erin, u4402564en_AU
local.contributor.authoruidCherbuin, Nicolas, u3184049en_AU
local.description.notesImported from ARIESen_AU
local.identifier.absfor420600 - Public healthen_AU
local.identifier.ariespublicationa383154xPUB22129en_AU
local.identifier.citationvolume10en_AU
local.identifier.doi10.3390/jcm10040637en_AU
local.identifier.scopusID2-s2.0-85111443060
local.identifier.thomsonIDWOS:000623999900001
local.identifier.uidSubmittedBya383154en_AU
local.publisher.urlhttps://www.mdpi.com/2077-0383/10/4/637en_AU
local.type.statusPublished Versionen_AU

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