Higher Blood Pressure is Associated with Greater White Matter Lesions and Brain Atrophy: A Systematic Review with Meta-Analysis
dc.contributor.author | Alateeq, Khawlah | |
dc.contributor.author | Walsh, Erin | |
dc.contributor.author | Cherbuin, Nicolas | |
dc.date.accessioned | 2024-02-26T01:32:05Z | |
dc.date.available | 2024-02-26T01:32:05Z | |
dc.date.issued | 2021 | |
dc.date.updated | 2022-10-09T07:17:10Z | |
dc.description.abstract | Background: To summarise and quantify the evidence on the association between Blood pressure (BP), white matter lesions (WMLs), and brain volumes. Method: Electronic databases Pub-Med, Scopus, and Clarivate were searched in February 2020 using an established methodology and pre-determined search terms. Studies were eligible for inclusion if they reported on the association between BP and WMLs or brain volume in cognitively healthy individuals, while adjusting for age and intra-cranial volume. Results: Searches yielded 7509 articles, of which 52 (26 longitudinal and 33 cross-sectional), were eligible and had a combined sample size of 343,794 individuals. Analyses found that 93.7% of studies reported that higher BP was associated with poorer cerebral health (higher WMLs and lower brain volumes). Meta-analysis of compatible results indicated a dose-de-pendent relationship with every one standard deviation increase in systolic BP (SBP) above 120 mmHg being associated with a 11.2% (95% CI 2.3, 19.9, p = 0.0128) increase in WMLs and-0.13% (95% CI–0.25, −0.023, p = 0.0183) smaller hippocampal volume. Conclusion: The association between BP and brain volumes appears across the full range of BP measurements and is not limited to hypertensive individuals. Higher BP in community-residing individuals is associated with poorer cerebral health. | en_AU |
dc.format.mimetype | application/pdf | en_AU |
dc.identifier.issn | 2077-0383 | en_AU |
dc.identifier.uri | http://hdl.handle.net/1885/313894 | |
dc.language.iso | en_AU | en_AU |
dc.provenance | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | en_AU |
dc.publisher | MDPI | en_AU |
dc.rights | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | en_AU |
dc.rights.license | Creative Commons Attribution License | en_AU |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_AU |
dc.source | Journal of Clinical Medicine | en_AU |
dc.subject | blood pressure | en_AU |
dc.subject | white matter lesions | en_AU |
dc.subject | total brain | en_AU |
dc.subject | hippocampus | en_AU |
dc.subject | magnetic resonance imaging | en_AU |
dc.title | Higher Blood Pressure is Associated with Greater White Matter Lesions and Brain Atrophy: A Systematic Review with Meta-Analysis | en_AU |
dc.type | Journal article | en_AU |
dcterms.accessRights | Open Access | en_AU |
local.bibliographicCitation.issue | 4 | en_AU |
local.bibliographicCitation.lastpage | 19 | en_AU |
local.bibliographicCitation.startpage | 1 | en_AU |
local.contributor.affiliation | Alateeq, Khawlah, College of Health and Medicine, ANU | en_AU |
local.contributor.affiliation | Walsh, Erin, College of Health and Medicine, ANU | en_AU |
local.contributor.affiliation | Cherbuin, Nicolas, College of Health and Medicine, ANU | en_AU |
local.contributor.authoremail | u3184049@anu.edu.au | en_AU |
local.contributor.authoruid | Alateeq, Khawlah, u6816387 | en_AU |
local.contributor.authoruid | Walsh, Erin, u4402564 | en_AU |
local.contributor.authoruid | Cherbuin, Nicolas, u3184049 | en_AU |
local.description.notes | Imported from ARIES | en_AU |
local.identifier.absfor | 420600 - Public health | en_AU |
local.identifier.ariespublication | a383154xPUB22129 | en_AU |
local.identifier.citationvolume | 10 | en_AU |
local.identifier.doi | 10.3390/jcm10040637 | en_AU |
local.identifier.scopusID | 2-s2.0-85111443060 | |
local.identifier.thomsonID | WOS:000623999900001 | |
local.identifier.uidSubmittedBy | a383154 | en_AU |
local.publisher.url | https://www.mdpi.com/2077-0383/10/4/637 | en_AU |
local.type.status | Published Version | en_AU |
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