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The glucocorticoid receptor is required for experimental adrenocorticotrophic hormone-induced hypertension in mice

Date

Authors

Zhang, Yi

Schyvens, Chris

Cole, Timothy

McKenzie, Katja

Vickers, Janine

Whitworth, Judith

Publisher

Blackwell Science Asia

Abstract

1. In the present study, we have (i) measured basal blood pressure by telemetry in wild-type (WT) and glucocorticoid receptor knockout (GRKO) mice; (ii) investigated whether or not adrenocorticotrophic hormone (ACTH) can induce hypertension in GRKO mice;

Keywords

Keywords: corticotropin; glucocorticoid receptor; glucose; mineralocorticoid receptor; potassium; sodium; spironolactone; animal experiment; animal model; article; blood pressure measurement; controlled study; glucose blood level; hematocrit; hypertension; male; mo Blood pressure; Glucocorticoid receptors; Knockout mice

URI

http://hdl.handle.net/1885/27087

Collections

ANU Research Publications

Source

Clinical and Experimental Pharmacology and Physiology

Type

Journal article

DOI

10.1111/j.1440-1681.2010.05429.x

Restricted until

2037-12-31

Downloads

File

Description

01_Zhang_The_glucocorticoid_receptor_is_2010.pdf (32.24 KB)

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