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Pulmonary tuberculosis, impaired lung function, disability and quality of life in a high-burden setting

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dc.contributor.authorMaguire, Graeme
dc.contributor.authorAnstey, Nicholas
dc.contributor.authorArdian, M
dc.contributor.authorWaramori, G
dc.contributor.authorTjitra, Emiliana
dc.contributor.authorKenangalem, Enny
dc.contributor.authorHandojo, Tjandra
dc.contributor.authorKelly, Paul
dc.date.accessioned2015-12-08T22:17:46Z
dc.date.issued2009
dc.date.updated2016-02-24T11:16:55Z
dc.description.abstractSETTING: Tuberculosis treatment clinic in Papua, Indonesia. OBJECTIVE: To document the impact of pulmonary tuberculosis (PTB) on lung function, exercise tolerance and quality of life (QOL). DESIGN: A prospective cohort study of 115 patients with smear-positive PTB followed for 6 months. Demographics, disease history, sputum microbiology, spirometry, 6-minute weight.walk distance (6MWWD) and QOL (modified St George's Respiratory Questionnaire) were measured at diagnosis and at 2 and 6 months. Analysis was restricted to the 69/115 (60%) subjects who attended all follow-up visits. RESULTS: Subjects who attended all visits were less likely than the full cohort to be of Papuan ethnicity (P < 0.05), were more likely to be cured (P < 0.001) and had better lung function at diagnosis (P < 0.05). Significant lung function impairment (forced expiratory volume in 1 second [FEV1] <60% predicted) was found in 27/69 (39%) at diagnosis. Although this fell during treatment (P < 0.01), 17/69 (24.6%) had persisting significant lung function impairment at treatment completion. As lung function recovered, exercise tolerance (6MWWD) rose by 12.3% (P < 0.001) and QOL improved (P < 0.001). CONCLUSION: In a high-burden setting, PTB causes prolonged, significant impairment of lung function, exercise tolerance and QOL. Current measures of disease burden are likely to underestimate the true impact of disease. Earlier diagnosis and disease-modifying treatments may reduce the long-term impact of PTB.
dc.identifier.issn1027-3719
dc.identifier.urihttp://hdl.handle.net/1885/31047
dc.publisherInternational Union against Tuberculosis and Lung Disease
dc.sourceInternational Journal of Tuberculosis and Lung Disease
dc.subjectKeywords: adult; anamnesis; article; controlled study; convalescence; ethnicity; exercise tolerance; female; follow up; forced expiratory volume; human; lung disease; lung function; lung tuberculosis; major clinical study; male; medical documentation; physical disa Exercise tolerance; Indonesia; Quality of life; Spirometry; Tuberculosis
dc.titlePulmonary tuberculosis, impaired lung function, disability and quality of life in a high-burden setting
dc.typeJournal article
local.bibliographicCitation.issue12
local.bibliographicCitation.lastpage1506
local.bibliographicCitation.startpage1500
local.contributor.affiliationMaguire, Graeme, Menzies School of Health Research
local.contributor.affiliationAnstey, Nicholas, Menzies School of Health Research
local.contributor.affiliationArdian, M, District Ministry of Health
local.contributor.affiliationWaramori, G, Public Health & Malaria Control Department
local.contributor.affiliationTjitra, Emiliana, Ministry of Health, Indonesia
local.contributor.affiliationKenangalem, Enny, Mitra Masyrakat Hopsital
local.contributor.affiliationHandojo, Tjandra, Mitra Masyrakat Hospital
local.contributor.affiliationKelly, Paul, College of Medicine, Biology and Environment, ANU
local.contributor.authoremailu4323806@anu.edu.au
local.contributor.authoruidKelly, Paul, u4323806
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor111706 - Epidemiology
local.identifier.ariespublicationu4637548xPUB79
local.identifier.citationvolume13
local.identifier.scopusID2-s2.0-74949120502
local.identifier.thomsonID000272726800010
local.identifier.uidSubmittedByu4637548
local.type.statusPublished Version

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