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MCD-induced steatohepatitis is associated with hepatic adiponectin resistance and adipogenic transformation of hepatocytes

Date

Authors

Larter, Claire

Yeh, Matthew

Williams, Jacqueline

Bell-Anderson, Kim S

Farrell, Geoffrey

Publisher

W B Saunders Co

Abstract

Background/Aims: In these studies, we tested the hypothesis that increased lipid intake would exacerbate the severity of nutritional steatohepatitis. Methods: C57Bl/6J mice were fed methionine-and-choline deficient (MCD) diets containing 20% (high) or 5%

Keywords

Keywords: adiponectin; alanine aminotransferase; apolipoprotein A2; choline; lipid; lipid peroxide; messenger RNA; methionine; peroxisome proliferator activated receptor gamma; triacylglycerol; alanine aminotransferase blood level; animal experiment; animal model; Adipokine; High-fat diet; Non-alcoholic fatty liver disease; Peroxisome proliferator-activated receptor

URI

http://hdl.handle.net/1885/25117

Collections

ANU Research Publications

Source

Hepatology

Type

Journal article

DOI

10.1016/j.jhep.2008.03.026

Restricted until

2037-12-31

Downloads

File

Description

01_Larter_MCD-induced_steatohepatitis_is_2008.pdf (623.54 KB)

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