Correlation of central versus peripheral macular structure-function with acuity in age-related macular degeneration

dc.contributor.authorSabeti, Faran
dc.contributor.authorLane, Jo
dc.contributor.authorRohan, Emilie
dc.contributor.authorRai, Bhim Bahadur
dc.contributor.authorEssex, Rohan
dc.contributor.authorMcKone, Elinor
dc.contributor.authorMaddess, Ted
dc.date.accessioned2022-10-21T03:28:26Z
dc.date.available2022-10-21T03:28:26Z
dc.date.issued2021
dc.date.updated2023-09-17T08:15:54Z
dc.description.abstractPurpose: Patients with advanced age-related macular degeneration (AMD) may have preserved visual function despite significant retinal structural changes. We aimed to evaluate the relationships among retinal thickness, macular sensitivity, and visual acuity (VA) in advanced AMD. Methods: We examined 43 eyes of 22 patients with advanced AMD (ages 66–93 years), prospectively recruited from the Canberra Hospital Ophthalmology Department. Visual function was measured on participants with low and high contrast visual acuity (LCVA and HCVA) and 10-2 Matrix visual fields. Retinal structure was determined with spectral domain optical coherence tomography (OCT), and customized software mapped the 64 OCT macular thickness regions onto the 44 regions of the 10-2 test. Results: Median retinal thickness at each 10-2 region was near normal. Just 7 of 88 regions from the OCT analysis that were thicker than the median had sensitivity that declined significantly with increasing thickness (r = −0.698 ± 0.082, mean ± SD), whereas 17 of 88 thinner regions showed significantly decreasing sensitivity with decreasing thickness (r = 0.723 ± 0.078). The absolute value of deviations from median optical coherence tomography thickness (aOCT) outside the central eight degrees was significantly correlated with HCVA (r = −0.34, P = 0.047). Thickness in the central eight degrees was not. Similarly, matrix sensitivities inside the central eight degrees were significantly correlated with outer aOCT (r = −0.49, P = 0.002). Conclusions: Retinal thickness outside eight degrees were significantly associated with HCVA and macular sensitivity. These results suggest that outer macular thickness may be a useful prognostic indicator in AMD. Translational Relevance: Retinal structure at the borders of the macula may be a surro-gate marker of vision and retinal thickness near fixation.
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn2164-2591en_AU
dc.identifier.urihttp://hdl.handle.net/1885/275711
dc.language.isoen_AUen_AU
dc.provenanceThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licenseen_AU
dc.publisherARVO
dc.rights© 2021 The Author(s)
dc.rights.licenseCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_AU
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_AU
dc.sourceTranslational Vision Science & Technology
dc.subjectage-related macular degeneration (AMD)
dc.subjectvisual function
dc.subjectretinal structure
dc.titleCorrelation of central versus peripheral macular structure-function with acuity in age-related macular degeneration
dc.typeJournal article
dcterms.accessRightsOpen Accessen_AU
local.bibliographicCitation.issue2en_AU
local.bibliographicCitation.lastpage12en_AU
local.bibliographicCitation.startpage1en_AU
local.contributor.affiliationSabeti, Faran, College of Health and Medicine, ANUen_AU
local.contributor.affiliationLane, Jo, College of Health and Medicine, ANUen_AU
local.contributor.affiliationRohan, Emilie, College of Health and Medicine, ANUen_AU
local.contributor.affiliationRai, Bhim, College of Health and Medicine, ANUen_AU
local.contributor.affiliationEssex, Rohan, The Canberra Hospitalen_AU
local.contributor.affiliationMcKone, Elinor, College of Health and Medicine, ANUen_AU
local.contributor.affiliationMaddess, Ted, College of Health and Medicine, ANUen_AU
local.contributor.authoremailu8103614@anu.edu.auen_AU
local.contributor.authoruidSabeti, Faran, u4489908en_AU
local.contributor.authoruidLane, Jo, u4538815en_AU
local.contributor.authoruidRohan, Emilie, u5687443en_AU
local.contributor.authoruidRai, Bhim, u5897741en_AU
local.contributor.authoruidMcKone, Elinor, u8703821en_AU
local.contributor.authoruidMaddess, Ted, u8103614en_AU
local.description.notesImported from ARIESen_AU
local.identifier.absfor321201 - Ophthalmologyen_AU
local.identifier.absseo200101 - Diagnosis of human diseases and conditionsen_AU
local.identifier.ariespublicationa383154xPUB17767en_AU
local.identifier.citationvolume10en_AU
local.identifier.doi10.1167/tvst.10.2.10en_AU
local.identifier.scopusID2-s2.0-85100923550
local.identifier.thomsonIDWOS:000635403100010
local.identifier.uidSubmittedBya383154en_AU
local.publisher.urlhttps://tvst.arvojournals.org/en_AU
local.type.statusPublished Versionen_AU

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