Factors dictating carbene formation at (PNP)Ir

Date

2010

Authors

Brookes, Nigel J
Whited, Matthew
Ariafard, Alireza
Stranger, Robert
Grubbs, Robert
Yates, Brian F

Journal Title

Journal ISSN

Volume Title

Publisher

American Chemical Society

Abstract

The mechanistic subtleties involved with the interaction of an amido/bis(phosphine)-supported (PNP)Ir fragment with a series of linear and cyclic ethers have been investigated using density functional theory. Our analysis has revealed the factors dictating reaction direction toward either an iridium-supported carbene or a vinyl ether adduct. The (PNP)Ir structure will allow carbene formation only from accessible carbons α to the ethereal oxygen, such that d electron back-donation from the metal to the carbene ligand is possible. Should these conditions be unavailable, the main competing pathway to form vinyl ether can occur, but only if the (PNP)Ir framework does not sterically interfere with the reacting ether. In situations where steric hindrance prevents unimpeded access to both pathways, the reaction may progress to the initial C-H activation but no further. Our mechanistic analysis is density functional independent and whenever possible confirmed experimentally by trapping intermediate species experimentally. We have also highlighted an interesting systematic error present in the DFT analysis of reactions where steric environment alters considerably within a reaction.

Description

Keywords

Keywords: Back-donation; C-h activation; Carbene ligands; Carbenes; Cyclic ether; D electrons; Density functionals; Intermediate specie; Mechanistic analysis; Reaction directions; Steric hindrances; Vinyl ethers; Activation analysis; Density functional theory; Ethe

Citation

Source

Organometallics

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1021/om100211a

Restricted until

2037-12-31