Methamphetamine-induced conditioned place preference in LG/J and SM/J mouse strains and an F45/F46 advanced intercross line

dc.contributor.authorBryant, Camron D.
dc.contributor.authorKole, Loren A.
dc.contributor.authorGuido, Michael A.
dc.contributor.authorCheng, Riyan
dc.contributor.authorPalmer, Abraham A.
dc.date.accessioned2016-02-03T00:46:38Z
dc.date.available2016-02-03T00:46:38Z
dc.date.issued2012-07-11
dc.date.updated2016-02-24T09:32:43Z
dc.description.abstractThe conditioned place preference (CPP) test is frequently used to evaluate the rewarding properties of drugs of abuse in mice. Despite its widespread use in transgenic and knockout experiments, there are few forward genetic studies using CPP to identify novel genes contributing to drug reward. In this study, we tested LG/J and SM/J inbred strains and the parents/offspring of 10 families of an F(45)/F(46) advanced intercross line (AIL) for methamphetamine-induced CPP (MA-CPP) once per week over 2 weeks. Both LG/J and SM/J mice exhibited significant MA-CPP that was not significantly different between the two strains. Furthermore, LG/J mice showed significantly less acute MA-induced locomotor activity as well as locomotor sensitization following subsequent MA injections. AIL mice (N = 105) segregating LG/J and SM/J alleles also demonstrated significant MA-CPP that was equal in magnitude between the first and second week of training. Importantly, MA-CPP in AIL mice did not correlate with drug-free or MA-induced locomotor activity, indicating that MA-CPP was not confounded by test session activity and implying that MA-CPP is genetically distinct from acute psychomotor sensitivity. We estimated the heritability of MA-CPP and locomotor phenotypes using midparent-offspring regression and maximum likelihood estimates derived from the kinship coefficients of the AIL pedigree. Heritability estimates of MA-CPP were low (0-0.21) and variable (SE = 0-0.33) which reflected our poor power to estimate heritability using only 10 midparent-offspring observations. In sum, we established a short-term protocol for MA-CPP in AIL mice that could reveal LG/J and SM/J alleles important for MA reward. The use of highly recombinant genetic populations like AIL should facilitate the identification of these genes and may have implications for understanding psychostimulant abuse in humans.
dc.description.sponsorshipThis work was supported by R01DA021336 and K99DA029635.en_AU
dc.identifier.issn1664-8021en_AU
dc.identifier.urihttp://hdl.handle.net/1885/97401
dc.publisherFrontiers Research Foundation
dc.rights© 2012 Bryant, Kole, Guido, Cheng and Palmer. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
dc.sourceFrontiers in Genetics
dc.subjectaddiction
dc.subjectamphetamine
dc.subjectcue-associated craving
dc.subjectdrug abuse
dc.subjectlocomotion
dc.subjectpavlovian conditioning
dc.subjectpsychostimulants
dc.subjectreinforcement
dc.titleMethamphetamine-induced conditioned place preference in LG/J and SM/J mouse strains and an F45/F46 advanced intercross line
dc.typeJournal article
local.bibliographicCitation.issueJUL
local.bibliographicCitation.lastpage8)
local.bibliographicCitation.startpage126en_AU
local.contributor.affiliationBryant, Camron D , The University of Chicago, United States of Americaen_AU
local.contributor.affiliationKole, Loren A , The University of Chicago, United States of Americaen_AU
local.contributor.affiliationGuido, Michael A, The University of Chicago, United States of Americaen_AU
local.contributor.affiliationCheng, Riyan, College of Medicine, Biology and Environment, CMBE Research School of Biology, Division of Plant Sciences, The Australian National Universityen_AU
local.contributor.affiliationPalmer, Abraham A, The University of Chicago, United States of Americaen_AU
local.contributor.authoremailriyan.cheng@anu.edu.auen_AU
local.contributor.authoruidu5264559en_AU
local.description.notesImported from ARIESen_AU
local.identifier.absfor060410en_AU
local.identifier.absfor060412en_AU
local.identifier.absseo970106en_AU
local.identifier.ariespublicationf5625xPUB7052en_AU
local.identifier.citationvolume3en_AU
local.identifier.doi10.3389/fgene.2012.00126en_AU
local.identifier.essn1664-8021en_AU
local.identifier.scopusID2-s2.0-84876021130
local.identifier.uidSubmittedByu3488905en_AU
local.publisher.urlhttp://www.frontiersin.org/en_AU
local.type.statusPublished Versionen_AU

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