Mice Deficient in Glutathione tranferase Zeta/Maleylacetoacetate Isomerase Exhibit a Range of Pathological Changes and Elevated Expression of Alpha, Mu, and Pi Class Glutathione Transferases

Date

2004

Authors

Lim, Cindy
Matthaei, Klaus
Blackburn, Anneke
Davis, Richard
Koina, Mark
Anders, Michael
Board, Philip
Dahlstrom, Jane

Journal Title

Journal ISSN

Volume Title

Publisher

American Society for Investigative Pathology

Abstract

Glutathione transferase zeta (GSTZ1-1) is the major enzyme that catalyzes the metabolism of α-halo acids such as dichloroacetic acid, a carcinogenic contaminant of chlorinated water. GSTZ1-1 is identical with maleylacetoacetate isomerase, which catalyzes

Description

Keywords

Keywords: dichloroacetic acid; glutathione transferase; glutathione transferase alpha; glutathione transferase zeta; isomerase; maleylacetoacetate isomerase; mu glutathione transferase; oxidoreductase; phenylalanine; pi glutathione transferase; quinone oxidoreducta

Citation

Source

American Journal of Pathology

Type

Journal article

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DOI

Restricted until

2037-12-31