Mice Deficient in Glutathione tranferase Zeta/Maleylacetoacetate Isomerase Exhibit a Range of Pathological Changes and Elevated Expression of Alpha, Mu, and Pi Class Glutathione Transferases
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Lim, Cindy
Matthaei, Klaus
Blackburn, Anneke
Davis, Richard
Koina, Mark
Anders, Michael
Board, Philip
Dahlstrom, Jane
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American Society for Investigative Pathology
Abstract
Glutathione transferase zeta (GSTZ1-1) is the major enzyme that catalyzes the metabolism of α-halo acids such as dichloroacetic acid, a carcinogenic contaminant of chlorinated water. GSTZ1-1 is identical with maleylacetoacetate isomerase, which catalyzes
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American Journal of Pathology
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2037-12-31
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