Mice Deficient in Glutathione tranferase Zeta/Maleylacetoacetate Isomerase Exhibit a Range of Pathological Changes and Elevated Expression of Alpha, Mu, and Pi Class Glutathione Transferases
Date
2004
Authors
Lim, Cindy
Matthaei, Klaus
Blackburn, Anneke
Davis, Richard
Koina, Mark
Anders, Michael
Board, Philip
Dahlstrom, Jane
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American Society for Investigative Pathology
Abstract
Glutathione transferase zeta (GSTZ1-1) is the major enzyme that catalyzes the metabolism of α-halo acids such as dichloroacetic acid, a carcinogenic contaminant of chlorinated water. GSTZ1-1 is identical with maleylacetoacetate isomerase, which catalyzes
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Keywords: dichloroacetic acid; glutathione transferase; glutathione transferase alpha; glutathione transferase zeta; isomerase; maleylacetoacetate isomerase; mu glutathione transferase; oxidoreductase; phenylalanine; pi glutathione transferase; quinone oxidoreducta
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American Journal of Pathology
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Journal article
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2037-12-31
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