Murine dendritic cell development: Difficulties associated with subset analysis

dc.contributor.authorWilson, Heather
dc.contributor.authorO'Neill, Helen
dc.date.accessioned2015-12-13T23:08:17Z
dc.date.issued2003
dc.date.updated2015-12-12T08:12:56Z
dc.description.abstractDendritic cells are bone marrow-derived professional antigen presenting cells that play major roles in both the induction of primary immune responses and tolerance. It has become clear that dendritic cells are a heterogenous group of cells that vary in cell surface marker expression and function. Multiple dendritic cell subsets have now been defined in mouse lymphoid organs and peripheral tissues. A knowledge of the function and relationship between dendritic cell subsets will be essential for understanding the regulation of immune homeostasis, immune responses and tolerance. While an increasing number of dendritic cell progenitors are being identified, the pathways that connect them remain unclear. In addition, it is unclear whether the functional divisions reflect maturation status, subset specialization or functional plasticity in response to specific pathogen and environmental signals. This review summarizes the current knowledge about the function and lineage relationship of dendritic cell subsets. It also discusses some of the difficulties associated with dendritic cell subset analysis.
dc.identifier.issn0818-9641
dc.identifier.urihttp://hdl.handle.net/1885/86608
dc.publisherBlackwell Publishing Ltd
dc.sourceImmunology and Cell Biology
dc.subjectKeywords: cell surface marker; antigen expression; antigen presenting cell; bone marrow cell; cell function; cell maturation; cellular distribution; dendritic cell; hematopoiesis; homeostasis; human; immune response; immunological tolerance; lymphoid tissue; nonhum Cell development; Dendritic cells; Haemopoiesis; Lineage
dc.titleMurine dendritic cell development: Difficulties associated with subset analysis
dc.typeJournal article
local.bibliographicCitation.issue4
local.bibliographicCitation.lastpage246
local.bibliographicCitation.startpage239
local.contributor.affiliationWilson, Heather, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationO'Neill, Helen, College of Medicine, Biology and Environment, ANU
local.contributor.authoremailu8100137@anu.edu.au
local.contributor.authoruidWilson, Heather, u9718281
local.contributor.authoruidO'Neill, Helen, u8100137
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor110799 - Immunology not elsewhere classified
local.identifier.ariespublicationMigratedxPub15523
local.identifier.citationvolume81
local.identifier.doi10.1046/j.1440-1711.2003.t01-1-01165.x
local.identifier.scopusID2-s2.0-0041846758
local.identifier.uidSubmittedByMigrated
local.type.statusPublished Version

Downloads

Original bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
01_Wilson_Murine_dendritic_cell_2003.pdf
Size:
98.04 KB
Format:
Adobe Portable Document Format
Back to topicon-arrow-up-solid
 
APRU
IARU
 
edX
Group of Eight Member

Acknowledgement of Country

The Australian National University acknowledges, celebrates and pays our respects to the Ngunnawal and Ngambri people of the Canberra region and to all First Nations Australians on whose traditional lands we meet and work, and whose cultures are among the oldest continuing cultures in human history.


Contact ANUCopyrightDisclaimerPrivacyFreedom of Information

+61 2 6125 5111 The Australian National University, Canberra

TEQSA Provider ID: PRV12002 (Australian University) CRICOS Provider Code: 00120C ABN: 52 234 063 906